天然半柔性/柔性聚阴离子混合物中聚集的抑制，以及使用SANS直接检验OSF模型
Suppression of Aggregation in Natural-Semiflexible/Flexible Polyanion Mixtures, and Direct Check of the OSF Model using SANS
摘要：
当生物半柔性的透明质酸（HA）嵌入另一种带负电荷的柔性α链（聚苯乙烯磺酸钠）的混合物中时，其聚集和其他相互作用受到抑制。我们使用小角中子散射、同位素标记和对比度匹配，仅在混合物中直接看到HA。在低离子强度下，通常在纯HA溶液中观察到聚集，一组明确的实验结果表明，我们既没有观察到HA聚集，也没有观察到HA峰（观察单一物质的溶液）;相反，我们观察到单链的蠕虫状链行为特征，其持续长度随德拜屏蔽长度的平方Le~κ^-2而变化，如Odijk先前所预测的，但尚未在聚合物链上观察到。
英文摘要：
Aggregation and other interactions are suppressed for a biological semiflexible polyelectrolyte, hyaluronan (HA), when it is embedded in a mixture with another negatively charged and flexible polyelectrolyte chain, sodium polystyrene sulfonate. We see directly HA only in the mixture using Small-Angle Neutron Scattering, isotopic labelling and contrast matching. At low ionic strength, for which aggregation is usually seen for pure HA solutions, an unambiguous set of experimental results shows that we neither observe HA aggregation nor a polyelectrolyte peak (observed for solutions of single species); instead we observe a wormlike chain behaviour characteristic of single chain with a variation of the persistence length with the square of the Debye screening length, Le~κ^-2, as formerly predicted by Odijk and not yet observed on a polymer chain.
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