顺式调控模块驱动多细胞系统的动态模式
Cis-Regulatory Modules Drive Dynamic Patterns of a Multicellular System
摘要：
细胞内和细胞外信号如何通过转录因子整合对于理解群体水平上复杂的细胞模式至关重要。在这封信中，通过使用一个合成的基因振荡器耦合到群体感应装置，我们提出了一个实验可行的顺式调节模块（CRM）进行四种可能的逻辑操作（ANDN，ORN，NOR和NAND）的输入信号。我们在数值上和理论上表明，这些不同的标准物质驱动根本不同的动态模式，如同步，集群和splay状态。
英文摘要：
How intracellular and extracellular signals are integrated by transcription factors is essential for understanding complex cellular patterns at the population level. In this Letter, by using a synthetic genetic oscillator coupled to a quorum-sensing apparatus, we propose an experimentally feasible cis-regulatory module (CRM) which performs four possible logic operations (ANDN, ORN, NOR and NAND) of input signals. We show both numerically and theoretically that these different CRMs drive fundamentally different dynamic patterns, such as synchronization, clustering and splay state.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
