进化个体模型和真实网络中模块性的自发涌现
Spontaneous Emergence of Modularity in a Model of Evolving Individuals and in Real Networks
摘要:
我们调查的选择力,促进自然界中出现的模块化。我们展示了在不断变化的环境中进化的个体群体中模块化的自发出现。我们表明,模块化水平与环境变化的速度和严重性。模块化出现作为一个协同响应的噪音在环境中的水平基因转移的存在。我们认为,在自然界中观察到的层次结构可能是一个破缺的对称性状态,这一般是由于在不断变化的环境中的进化。为了支持我们的研究结果,我们分析了蛋白质相互作用的实验数据,并表明随着过去40亿年的进化,蛋白质相互作用网络变得越来越模块化。我们还讨论了一种方法来确定一个蛋白质的发散时间。
英文摘要:
We investigate the selective forces that promote the emergence of modularity in nature. We demonstrate the spontaneous emergence of modularity in a population of individuals that evolve in a changing environment. We show that the level of modularity correlates with the rapidity and severity of environmental change. The modularity arises as a synergistic response to the noise in the environment in the presence of horizontal gene transfer. We suggest that the hierarchical structure observed in the natural world may be a broken symmetry state, which generically results from evolution in a changing environment. To support our results, we analyze experimental protein interaction data and show that protein interaction networks became increasingly modular as evolution proceeded over the last four billion years. We also discuss a method to determine the divergence time of a protein.
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