静纤毛的连贯运动保证毛细胞转导通道的协调门控
Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels
摘要：
毛细胞的机械感受器，毛束，是高度敏感的，因为它的转导通道开放在一个非常狭窄的位移范围。转导通道的同步门控也是活跃的毛束运动的基础，毛束运动放大和调节反应性。独立转导通道的门控协调程度取决于个体静纤毛作为一个单元被约束移动的紧密程度。在牛蛙的球囊中使用双光束干涉测量，我们发现静纤毛的热运动距离远，如一束的相对边缘显示出高的相干性和可忽略的相位滞后。由于静纤毛的机械自由度受到强烈约束，因此在发束中任何位置施加的力都会使结构作为一个单元偏转。该特征确保了转导通道的协调门控，其最大化了机械电转导的灵敏度并增强了毛束放大其输入的能力。
英文摘要：
The hair cell's mechanoreceptive organelle, the hair bundle, is highly sensitive because its transduction channels open over a very narrow range of displacements. The synchronous gating of transduction channels also underlies the active hair-bundle motility that amplifies and tunes responsiveness. The extent to which the gating of independent transduction channels is coordinated depends on how tightly individual stereocilia are constrained to move as a unit. Using dual-beam interferometry in the bullfrog's sacculus, we found that thermal movements of stereocilia located as far apart as a bundle's opposite edges display high coherence and negligible phase lag. Because the mechanical degrees of freedom of stereocilia are strongly constrained, a force applied anywhere in the hair bundle deflects the structure as a unit. This feature assures the concerted gating of transduction channels that maximizes the sensitivity of mechanoelectrical transduction and enhances the hair bundle's capacity to amplify its inputs.
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