微流控器件中液滴的微波介电加热
Microwave Dielectric Heating of Drops in Microfluidic Devices
摘要：
我们提出了一种技术，局部和快速加热微流体装置中的水滴微波介电加热。水比聚合物、玻璃和油更有效地吸收微波功率，这是由于其在GHz频率下具有大的介电损耗的永久分子偶极矩。系统的相关热容量是单个热隔离的皮升水滴，这使得能够实现非常快的热循环。我们展示了微波介电加热的微流体装置，集成了一个流聚焦液滴制造商，液滴分离器，和金属电极局部提供微波功率从一个便宜的，市售的3.0 GHz的源和放大器。通过观察悬浮在水滴中的硒化镉纳米晶体的温度依赖性荧光强度来测量水滴的温度。我们展示了短至15 ms的特征加热时间，以达到比微流体装置的基准温度高30 ℃的稳态温度。许多常见的生物和化学应用需要快速和局部控制温度，例如DNA的PCR扩增，并且可以从这种新技术中受益。
英文摘要：
We present a technique to locally and rapidly heat water drops in microfluidic devices with microwave dielectric heating. Water absorbs microwave power more efficiently than polymers, glass, and oils due to its permanent molecular dipole moment that has a large dielectric loss at GHz frequencies. The relevant heat capacity of the system is a single thermally isolated picoliter drop of water and this enables very fast thermal cycling. We demonstrate microwave dielectric heating in a microfluidic device that integrates a flow-focusing drop maker, drop splitters, and metal electrodes to locally deliver microwave power from an inexpensive, commercially available 3.0 GHz source and amplifier. The temperature of the drops is measured by observing the temperature dependent fluorescence intensity of cadmium selenide nanocrystals suspended in the water drops. We demonstrate characteristic heating times as short as 15 ms to steady-state temperatures as large as 30 degrees C above the base temperature of the microfluidic device. Many common biological and chemical applications require rapid and local control of temperature, such as PCR amplification of DNA, and can benefit from this new technique.
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