在没有ATP的情况下基于F1-ATPase的摇动棘轮
Rocking ratchet based on F1-ATPase in the absence of ATP
摘要：
Bartussek，Hanggi和Kissner研究了摇摆棘轮系统，其中布朗粒子受到非对称周期势和振荡力的影响，并发现宏观电流的方向可以通过改变表征模型的参数值来逆转[Europhys.信件：28（1994）459]。在这封信中，我们应用他们的棘轮理论旋转马达蛋白，F1-ATP酶。在这项工作中，我们构建了一个模型的摇摆棘轮，其中F1-ATP酶旋转的结果，ATP水解，但通过振荡力的影响。然后，我们研究的基础上的分子动力学模拟的粗粒度蛋白质模型的F1-ATP酶的运动。虽然在没有ATP的情况下，当没有振荡力时，F1-ATP酶表现出无方向的布朗运动，但当我们施加振荡力时，我们观察到定向运动。此外，我们观察到，当我们改变振荡频率时，旋转方向被反转。
英文摘要：
Bartussek, Hanggi and Kissner studied a rocking ratchet system, in which a Brownian particle is subject to an asymmetric periodic potential together with an oscillating force, and found that the direction of the macroscopic current can be reversed by changing the parameter values characterizing the model [Europhys. Lett., 28 (1994) 459]. In this letter, we apply their ratchet theory to a rotary motor-protein, F1-ATPase. In this work, we construct a model of a rocking ratchet in which F1-ATPase rotates not as a result of ATP hydrolysis but through the influence of an oscillating force. We then study the motion of F1-ATPase on the basis of molecular dynamics simulations of this coarse-grained protein model. Although in the absence of ATP, F1-ATPase exhibits directionless Brownian motion when there exists no oscillating force, we observe directional motion when we do apply an oscillating force. Furthermore, we observe that the direction of rotation is reversed when we change the oscillation frequency.
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