节段间跳跃易化扩散的定量方法
Quantitative approach to facilitated diffusion with intersegmental jumping
摘要：
我们研究了DNA卷曲对蛋白质沿着DNA轮廓散布的三维（3D）散装游览的搜索速率的影响。当DNA卷曲时，沿着DNA片段进行短的3D跳跃的蛋白质可以被已经环回到接近原始片段的外来DNA片段捕获。这些片段间的跳跃被证明是通过降低对DNA上先前访问过的位点进行重采样的趋势来提高对DNA上特定位点的搜索率。这里开发的模型提供了一个定量描述最近的单分子实验的限制性内切酶EcoRV促进扩散。
英文摘要：
We study the impact of DNA coiling on the search rate of proteins moving along the DNA contour interspersed by three-dimensional (3D) bulk excursions. When the DNA is coiled proteins performing short 3D hops along a DNA segment can be captured by foreign DNA segments that have looped back close to the original segment. These intersegmental jumps are shown to enhance the search rate for a specific site on the DNA by lowering the tendency to resample previously visited sites on the DNA. The model developed here offers a quantitative description of recent single molecule experiments on facilitated diffusion of restriction enzymes EcoRV.
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