细胞色素c氧化酶质子泵动力学
Kinetics of proton pumping in cytochrome c oxidase
摘要：
我们提出了一个简单的细胞色素c氧化酶模型，包括四个氧化还原中心和四个质子化位点，研究的时间演化的静电耦合电子和质子转移的一个单一的电子注入到酶。我们推导出一个系统的主方程的电子和质子状态的概率，并表明，一个有效的泵送质子跨膜可以得到一组合理的参数。所有四个实验观察到的动力学阶段出现自然从我们的模型。我们还计算了不同温度下泵效率对跨膜电压的依赖关系，并讨论了氧化还原驱动质子移位的可能机制。
英文摘要：
We propose a simple model of cytochrome c oxidase, including four redox centers and four protonable sites, to study the time evolution of electrostatically coupled electron and proton transfers initiated by the injection of a single electron into the enzyme. We derive a system of master equations for electron and proton state probabilities and show that an efficient pumping of protons across the membrane can be obtained for a reasonable set of parameters. All four experimentally observed kinetic phases appear naturally from our model. We also calculate the dependence of the pumping efficiency on the transmembrane voltage at different temperatures and discuss a possible mechanism of the redox-driven proton translocation.
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