生物活软组织的伪主动运动学约束：胶原网络的影响
A pseudo active kinematic constraint for a biological living soft tissue: an effect of the collagen network
摘要：
最近在哺乳动物心脏中的研究表明，左心室壁增厚是收缩期射血的重要机制，并且在收缩期间，心肌在肌纤维交叉方向上产生显著的应力。我们认为，胶原网络周围的肌肉纤维可以解释这些力学行为。为了验证这一假设，我们开发了一个模型的大变形响应的主动，不可压缩，非线性弹性和横观各向同性的活软组织（如心脏或动脉组织），其中我们包括结缔组织和肌肉纤维之间的耦合效应。然后，一个三维的有限元制定包括这个内部的伪主动运动约束。解析解和有限元解吻合得很好。数值结果表明，这种壁厚增厚效应与实验观测值一致，其数量级为数量级。
英文摘要：
Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber direction. We suggested that the collagen network surrounding the muscular fibers could account for these mechanical behaviors. To test this hypothesis we develop a model for large deformation response of active, incompressible, nonlinear elastic and transversely isotropic living soft tissue (such as cardiac or arteries tissues) in which we include a coupling effect between the connective tissue and the muscular fibers. Then, a three-dimensional finite element formulation including this internal pseudo-active kinematic constraint is derived. Analytical and finite element solutions are in a very good agreement. The numerical results show this wall thickening effect with an order of magnitude compatible with the experimental observations.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
