TranspoGene和microTranspoGene：转座元件对7种脊椎动物和无脊椎动物转录组的影响
TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates
摘要：
转座元件（TE）是可移动的遗传序列。在真核生物的进化过程中，TE被插入到活性蛋白质编码基因中，影响基因结构、表达和剪接模式以及蛋白质序列。TE的基因组插入还导致新的功能性非编码RNA如微小RNA的产生和表达。我们已经构建了TranspoGene数据库，该数据库涵盖了七种物种：人、小鼠、鸡、斑马鱼、果蝇、线虫和海鞘的蛋白质编码基因内的TE。根据基因内的位置将TE分类：近端启动子TE、外显子化TE（插入内含子内导致外显子产生）、外显子TE（插入现有外显子中）或内含子TE。TranspoGene包含有关TE的特定类型和家族、基因组和mRNA位置、序列、支持转录本登录和与TE共有序列比对的信息。该数据库还包含宿主基因特异性数据：基因名称、基因组位置、Swiss-Prot和RefSeq登录、与基因相关的疾病和剪接模式。此外，我们还创建了microTranspoGene：一个人类、小鼠、斑马鱼和线虫TE衍生microRNA的数据库。TranspoGene和micro-TranspoGene数据库可供对TE插入对真核转录组的影响感兴趣的研究人员使用。
英文摘要：
Transposed elements (TEs) are mobile genetic sequences. During the evolution of eukaryotes TEs were inserted into active protein-coding genes, affecting gene structure, expression and splicing patterns, and protein sequences. Genomic insertions of TEs also led to creation and expression of new functional non-coding RNAs such as micro- RNAs. We have constructed the TranspoGene database, which covers TEs located inside proteincoding genes of seven species: human, mouse, chicken, zebrafish, fruit fly, nematode and sea squirt. TEs were classified according to location within the gene: proximal promoter TEs, exonized TEs (insertion within an intron that led to exon creation), exonic TEs (insertion into an existing exon) or intronic TEs. TranspoGene contains information regarding specific type and family of the TEs, genomic and mRNA location, sequence, supporting transcript accession and alignment to the TE consensus sequence. The database also contains host gene specific data: gene name, genomic location, Swiss-Prot and RefSeq accessions, diseases associated with the gene and splicing pattern. In addition, we created microTranspoGene: a database of human, mouse, zebrafish and nematode TEderived microRNAs. The TranspoGene and micro- TranspoGene databases can be used by researchers interested in the effect of TE insertion on the eukaryotic transcriptome.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
