λ-原噬菌体诱导被模拟为裂解阻遏的合作失败模式
Lambda-prophage induction modeled as a cooperative failure mode of lytic repression
摘要：
我们分析了一个系统水平的模型，裂解阻遏噬菌体在大肠杆菌。利用可靠性理论分析了大肠杆菌的阻遏蛋白回路，表明阻遏蛋白回路由4个冗余元件组成，其失效模式为原噬菌体诱导。我们的模型反映了参与调控的特定生化机制，包括远程合作结合，以及对大肠杆菌中原噬菌体诱导的详细预测。大肠杆菌在紫外线照射下的生长曲线与实验数据吻合较好。
英文摘要：
We analyze a system-level model for lytic repression of lambda-phage in E. coli using reliability theory, showing that the repressor circuit comprises 4 redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultra-violet radiation are in good agreement with experimental data.
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