慢复制裂解病毒：假溶原性持久性和宿主内竞争
Slowly replicating lytic viruses: pseudolysogenic persistence and within-host competition
摘要：
我们研究了裂解病毒的种群动力学，这些病毒在生物体或细胞培养物内的分裂宿主细胞中缓慢复制，并发现了一系列允许病毒持续存在的病毒复制率，避免了宿主细胞的灭绝或病毒复制过快或过慢时病毒的稀释。对于多个病毒株之间的宿主内竞争，具有“稳定”复制速率的病毒株可以胜过具有更高或更低复制速率的另一个病毒株，因此病毒的自然选择稳定了病毒的持久性。然而，当复制率高于和低于“稳定”值的菌株同时存在时，菌株之间的竞争不会导致一个菌株的主导地位，而是导致它们的共存。
英文摘要：
We study the population dynamics of lytic viruses which replicate slowly in dividing host cells within an organism or cell culture, and find a range of viral replication rates that allows viruses to persist, avoiding extinction of host cells or dilution of viruses at too rapid or too slow viral replication. For the within-host competition between multiple viral strains, a strain with a "stable" replication rate could outcompete another strain with a higher or lower replication rate, therefore natural selection of viruses stabilizes the viral persistence. However, when strains with higher and lower than the "stable" value replication rates are both present, competition between strains does not result in dominance of one strain, but in their coexistence.
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