蛋白质静电在促进DEAD-box蛋白质催化中的作用
The Role of Protein Electrostatics in Facilitating the Catalysis of DEAD-box Proteins
摘要:
蛋白质的静电状态在催化、配体结合、蛋白质稳定性和变构效应的调节中起着至关重要的作用。静电状态被证明是保守的DEAD盒图案和证据表明,发生的结构变化,DEAD盒蛋白配体结合后改变的DEAD盒图案静电的方式,有利于催化作用的DEAD盒谷氨酸。
英文摘要:
Protein electrostatic states have been demonstrated to play crucial roles in catalysis, ligand binding, protein stability, and in the modulation of allosteric effects. Electrostatic states are demonstrated to appear conserved among DEAD-box motifs and evidence is presented that the structural changes that occur to DEAD box proteins upon ligand binding alter the DEAD-box motif electrostatics in a way the facilitates the catalytic role of the DEAD-box glutatmate.
机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。