生长细菌中蛋白质簇的自组织周期性
Self-organized periodicity of protein clusters in growing bacteria
摘要：
E.大肠杆菌在细胞两极形成簇，也沿细胞体横向形成簇，这种簇在信号传导中起重要作用。最近，使用荧光成像的实验表明，在细胞生长过程中，横向簇形成在沿细胞体大致周期性间隔的位置。在本文中，我们证明了在一个晶格模型，这种空间组织可以自发地从随机成核机制。同样的机制可以解释最近在大肠杆菌中观察到的错误折叠蛋白质的周期性聚集。杆菌
英文摘要：
Chemotaxis receptors in E. coli form clusters at the cell poles and also laterally along the cell body, and this clustering plays an important role in signal transduction. Recently, experiments using flourrescence imaging have shown that, during cell growth, lateral clusters form at positions approximately periodically spaced along the cell body. In this paper, we demonstrate within a lattice model that such spatial organization could arise spontaneously from a stochastic nucleation mechanism. The same mechanism may explain the recent observation of periodic aggregates of misfolded proteins in E. coli.
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