标准肿瘤学I期设计的一些显著特性
Some notable properties of the standard oncology phase I design
摘要：
我们确定了标准肿瘤学I期试验设计或3 + 3设计的三个特性。我们表明，标准设计隐含使用保序回归估计最大耐受剂量。接下来，我们说明标准设计和Ji et al.（2007）提出的贝叶斯设计之间的关系。在特定的模型规格下，对该贝叶斯设计进行轻微修改，将以与标准设计相同的方式分配处理。最后，我们提出的计算揭示了在最坏情况下的标准设计的行为，并比较其行为与其他3 + 3类设计。
英文摘要：
We identify three properties of the standard oncology phase I trial design or 3 + 3 design. We show that the standard design implicitly uses isotonic regression to estimate a maximum tolerated dose. We next illustrate the relationship between the standard design and a Bayesian design proposed by Ji et al. (2007). A slight modification to this Bayesian design, under a particular model specification, would assign treatments in a manner identical to the standard design. We finally present calculations revealing the behavior of the standard design in a worst case scenario and compare its behavior with other 3 + 3-like designs.
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