In this paper we deal with diffusive relaxation limits of nonlinear systems of Euler type modeling chemotactic movement of cells toward Keller--Segel type systems. The approximating systems are either hyperbolic--parabolic or hyperbolic--elliptic. They all feature a nonlinear pressure term arising from a \emph{volume filling effect} which takes into account the fact that cells do not interpenetrate. The main convergence result relies on compensated compactness tools and is obtained for large initial data under suitable assumptions on the approximating solutions. In order to justify such assumptions, we also prove an existence result for initial data which are small perturbation of a constant state. Such result is proven via classical Friedrichs's symmetrization and linearization. In order to simplify the coverage, we restrict to the two--dimensional case with periodical boundary conditions.
We study the solutions of the two-dimensional Keller-Segel system describing chemotaxis. The Keller-Segel system as well as the properties of the blow-up set has been extensively studied. In this paper we obtain generalized solutions for the Keller-Segel system in the sense of measures as the limit of two-different regularizations of it. We will show that the resulting limit measures, that are in some suitable sense global weak solutions of the Keller-Segel system, depend in the regularization.
We consider the stationary Keller-Segel system from chemotaxis in a ball and we show the existence of a solution concentrating at the boundary of the ball.
The existence and nonexistence of global in time solutions is studied for a class of equations generalizing the chemotaxis model of Keller and Segel. These equations involve Lévy diffusion operators and general potential type nonlinear terms.
The focus of this paper is on solutions to a two-dimensional Keller-Segel system containing sub-logistic sources. We show that the presence of sub-logistic terms is adequate to prevent blow-up phenomena even in strongly degenerate Keller-Segel systems. Our proof relies on several techniques, including parabolic regularity theory in Orlicz spaces, variational arguments, interpolation inequalities, and the Moser iteration method.
We consider the parabolic-parabolic two-dimensional Patlak-Keller-Segel problem. We prove the existence of stable blow-up dynamics in finite time in the radial case. We extend in this article the result of [36] for the parabolic-elliptic case.
We investigate nonlinear dynamics near an unstable constant equilibrium in the classical Keller-Segel model. Given any general perturbation of magnitude $δ$, we prove that its nonlinear evolution is dominated by the corresponding linear dynamics along a fixed finite number of fastest growing modes, over a time period of $ln(1/δ)$. Our result can be interpreted as a rigourous mathematical characterization for early pattern formation in the Keller-Segel model.
We consider the simplest parabolic-elliptic model of chemotaxis in the whole space in several dimensions. Criteria for the existence of radial global-in-time solutions in terms of suitable Morrey norms are derived.
We construct radial self-similar solutions of the, so called, minimal parabolic-elliptic Keller--Segel model in several space dimensions with radial, nonnegative initial conditions with are below the Chandrasekhar solution -- the singular stationary solution of this system.
We consider the simplest parabolic-elliptic model of chemotaxis in the whole space in several dimensions. Criteria for the blowup of radially symmetric solutions in terms of suitable Morrey spaces norms are derived.
In this paper we derive matched asymptotic expansions for a solution of the Keller-Segel system in two space dimensions for which the amount of mass aggregation is $8πN$, where $N=1,2,3,...$ Previously available asymptotics had been computed only for the case in which N=1.
We prove a blow-up criterion for the solutions to the $ν$-dimensional Patlak-Keller-Segel equation in the whole space. The condition is new in dimension three and higher. In dimension two it is exactly Dolbeault's and Perthame's blow-up condition, i.e., blow-up occurs if total mass exceeds $8π$ .
In this paper, we present local Hölder estimates for the degenerate Keller-Segel system \eqref{eq-cases-aligned-main-problem-of-Keller-Segel-System} below in the range of $m>1$ and $q>1$ before a blow-up of solutions. To deal with difficulties caused by the degeneracy of the operator, we find uniform estimates depending sup-norm of the density function and modified the energy estimates and intrinsic scales considered in Porous Medium Equation. As its application, the uniqueness of weak solution to \eqref{eq-cases-aligned-main-problem-of-Keller-Segel-System} is also showed in the class of Hölde…
This paper generalizes and extends to the case of nonlinear effects and logistic perturbations some results recently developed in the literature where, for the linear counterpart and in absence of logistics, criteria toward boundedness for an attraction-repulsion Keller-Segel system with double saturation are derived.
We study a new nonlocal approach to the mathematical modelling of the Chemotaxis problem, which describes the random motion of a certain population due a substance concentration. Considering the initial-boundary value problem for the fractional hyperbolic Keller-Segel model, we prove the solvability of the problem. The solvability result relies mostly on fractional calculus and kinetic formulation of scalar conservation laws.
We study a Keller-Segel type chemotaxis model with a modified sensitivity function in a bounded domain $Ω\subset \mathbb{R}^N$, $N\geq2$. The global existence of classical solutions to the fully parabolic system is established provided that the ratio of the chemotactic coefficient to the motility of cells is not too large.
In this paper we study the initial boundary value problem for the system $u_t-Δu^m=-\mbox{div}(u^{q}\nabla v),\ v_t-Δv+v=u$. This problem is the so-called Keller-Segel model with nonlinear diffusion. Our investigation reveals that nonlinear diffusion can prevent overcrowding. To be precise, we show that solutions are bounded as long as $m>q>0$, thereby substantially generalizing the known results in this area. Furthermore, our result seems to imply that the Keller-Segel model can have bounded solutions and blow-up ones simultaneously.
In two space dimensions, the parabolic-parabolic Keller--Segel system shares many properties with the parabolic-elliptic Keller--Segel system. In particular, solutions globally exist in both cases as long as their mass is less than 8?. However, this threshold is not as clear in the parabolic-parabolic case as it is in the parabolic-elliptic case, in which solutions with mass above 8? always blow up. Here we study forward self-similar solutions of the parabolic-parabolic Keller--Segel system and prove that, in some cases, such solutions globally exist even if their total mass is above 8?, which…
We construct weak global in time solutions to the classical Keller-Segel system cell movement by chemotaxis in two dimensions when the total mass is below the well-known critical value. Our construction takes advantage of the fact that the Keller-Segel system can be realized as a gradient flow in a suitable functional product space. This allows us to employ a hybrid variational principle which is a generalisation of the minimising implicit scheme for Wasserstein distances introduced by Jordan, Kinderlehrer and Otto (1998).
We introduce the planar helical flows on three dimensional torus and study the dissipation enhancement of such flows. We then use such flows as transport flows to solve the three dimensional advective Kuramoto-Sivashinsky and Keller-Segel equations. The global well-posedness of the Kuramoto-Sivashinsky equation is achieved when the linearized operator does not have growing mode in the direction orthogonal to the flow. The global classical solution of the three dimensional Keller-Segel is ensured for any size of the torus with arbitrarily large initial data.
We derive the two-dimensional Keller-Segel equation from a stochastic system of $N$ interacting particles in the case of sub-critical chemosensitivity $χ< 8 π$. The Coulomb interaction force is regularised with a cutoff of size $N^{- α}$, with arbitrary $α\in (0, 1 / 2)$. In particular we obtain a quantitative result for the maximal distance between the real and mean-field $N$-particle trajectories.
As it is well known, the parabolic-elliptic Keller-Segel system of chemotaxis on the plane has global-in-time regular nonnegative solutions with total mass below the critical value $8π$. Solutions with mass above $8π$ blow up in a finite time. We show that the case of the parabolic-parabolic Keller-Segel is different: each mass may lead to a global-in-time-solution, even if the initial data is a finite signed measure. These solutions need not be unique, even if we limit ourselves to nonnegative solutions.
We consider a Keller-Segel model coupled to the incompressible Navier-Stokes equations in spatial dimensions two and three. We establish the local existence of regular solutions and present some blow-up criteria for both cases that equations of oxygen concentration is of parabolic or hyperbolic type. We also prove global existence and decay estimate in time under the some smallness conditions of initial data.
In this paper, we consider the Cauchy problem for a generalized parabolic-elliptic Keller-Segel equation with fractional dissipation and the additional mixing effect of advection by an incompressible flow. Under suitable mixing condition on the advection, we study well-posedness of solution with large initial data. We establish the global $L^\infty$ estimate of the solution through nonlinear maximum principle, and obtain the global classical solution.
We investigate the one-dimensional Keller-Segel model where the diffusion is replaced by a non-local operator, namely the fractional diffusion with exponent $0<α\leq 2$. We prove some features related to the classical two-dimensional Keller-Segel system: blow-up may or may not occur depending on the initial data. More precisely a singularity appears in finite time when $α<1$ and the initial configuration of cells is sufficiently concentrated. On the opposite, global existence holds true for $α\leq1$ if the initial density is small enough in the sense of the $L^{1/α}$ norm.
The Keller-Segel model is a well-known system representing chemotaxis in living organisms. We study the convergence of a generalized nonlinear variant of the Keller-Segel to the degenerate Cahn-Hilliard system. This analysis is made possible from the observation that the Keller-Segel system is equivalent to a relaxed version of the Cahn-Hilliard system. Furthermore, this latter equivalent system has an interesting application in the modelling of living tissues. Indeed, compressible and incompressible porous medium type equations are widely used to describe the mechanical properties of living t…
We study the existence of steady states to the Keller-Segel system with linear chemotactical sensitivity function on a smooth bounded domain in $\mathbb R^N,$ $N\ge3,$ having rotational symmetry. We find three different types of chemoattractant concentration which concentrate along suitable $(N-2)-$dimensional minimal submanifolds of the boundary. The corresponding density of the cellular slime molds exhibit in the limit one or more Dirac measures supported on those boundary submanifolds.
We study the global in time existence of solutions to the parabolic-elliptic Patlak-Keller-Segel system of multi-species populations. We prove that if the initial mass satisfies an appropriate notion of sub-criticality, then the system has a solution defined for all time. We explore the gradient flow structure in the Wasserstein space to study the question of existence. Moreover, we show that the obtained solution satisfies energy dissipation inequality.
This paper deals with the Keller--Segel system with signal-dependent sensitivity \begin{align*} &u_t = Δu - χ\nabla \cdot (uS(v)\nabla v), &v_t = Δv - v + u, \end{align*} where $χ>0$ and $S$ is a given function generalizing the sensitivity $S(s)=\frac{1}{(a+s)^{k}}$, $k>1$, $a\ge 0$, and shows exponential convergence of global classical solutions under an additional smallness condition condition for $χ>0$.
We consider a Liouville-type PDE on a smooth bounded planar domain, which is related to stationary solutions of the Keller-Segel's model for chemotaxis. We prove existence of solutions under some algebraic conditions on the parameters. In particular, if the domain is not simply connected, then we can find solution for a generic choice of the parameters. We use variational and Morse-theoretical methods.
We consider the parabolic-elliptic Patlak-Keller-Segel (PKS) model of chemotactic aggregation in two space dimensions which describes the aggregation of bacteria under chemo-taxis. When the mass is equal to $8π$ and the second moment is finite (the doubly critical case), we give a precise description of the dynamic as time goes to infinity and extract the limiting profile and speed. The proof shows that this dynamic is stable under perturbations.
A simple proof of the existence of solutions for the two-dimensional Keller-Segel model with measures with all the atoms less than $8π$ as the initial data is given. This result has been obtained by Senba--Suzuki and Bedrossian--Masmoudi using different arguments. Moreover, we show a uniform bound for the existence time of solutions as well as an optimal hypercontractivity estimate.
The existence of generalised global supersolutions with a control upon the total muss is established for the parabolic-parabolic Keller-Segel system with logarithmic sensitivity for any space dimension. It is verified that smooth supersolutions of this sort are actually classical solutions. Unlike the previously existing constructions, neither is the chemotactic sensitivity coefficient required to be small, nor is it necessary for the initial data to be radially symmetric. Keywords: chemotaxis; generalised supersolution; global existence; logarithmic sensitivity
We study stationary solutions to the Keller--Segel equation on curved planes. We prove the necessity of the mass being $8 π$ and a sharp decay bound. Notably, our results do not require the solutions to have a finite second moment, and thus are novel already in the flat case. Furthermore, we provide a correspondence between stationary solutions to the static Keller--Segel equation on curved planes and positively curved Riemannian metrics on the sphere. We use this duality to show the nonexistence of solutions in certain situations. In particular, we show the existence of metrics, arbitrarily c…
We show that the Keller-Segel model in one dimension with Neumann boundary conditions and quadratic cellular diffusion has an intricate phase transition diagram depending on the chemosensitivity strength. Explicit computations allow us to find a myriad of symmetric and asymmetric stationary states whose stability properties are mostly studied via free energy decreasing numerical schemes. The metastability behavior and staircased free energy decay are also illustrated via these numerical simulations.
We prove the uniqueness of Hölder continuous weak solutions via duality argument and vanishing viscosity method for the Keller-Segel system of porous medium type equations coupled to the Stokes system in dimensions three. An important step is the estimate of the Green function of parabolic equations with lower order terms of variable coefficients, which seems to be of independent interest.
We consider a coupled Patlak-Keller-Segel-Navier-Stokes system in $\mathbb{R}^2$ that describes the collective motion of cells and fluid flow, where the cells are attracted by a chemical substance and transported by ambient fluid velocity, and the fluid flow is forced by the friction induced by the cells. The main result of the paper is to show the global existence of free-energy solutions to the 2D Patlak-Keller-Segel-Navier-Stokes system with critical and subcritical mass.
The coupled quasilinear Keller-Segel-Navier-Stokes system is considered under Neumann boundary conditions for $n$ and $c$ and no-slip boundary conditions for $u$ in three-dimensional bounded domains $Ω\subseteq \mathbb{R}^3$ with smooth boundary, where $m>0,κ\in \mathbb{R}$ are given constants, $ϕ\in W^{1,\infty}(Ω)$. If $ m> 2$, then for all reasonably regular initial data, a corresponding initial-boundary value problem for $(KSNF)$ possesses a globally defined weak solution.
We consider a two dimensional parabolic-elliptic Keller-Segel equation with a logistic forcing and a fractional diffusion of order $α$. We obtain existence of global in time regular solution for arbitrary initial data with no size restrictions and $c<α\leq 2$, where $c \in (0,2)$ depends on the equation's parameters. For an even wider range of $α's$, we prove existence of global in time weak solution for general initial data.
We prove the existence of global-in-time weak solutions to a version of the parabolic-parabolic Keller-Segel system in one spatial dimension. If the coupling of the system is suitably weak, we prove convergence of those solutions to the unique equilibrium with an exponential rate. Our proofs are based on an underlying gradient flow structure with respect to a mixed Wasserstein-$L^2$ distance.
The flux limited Keller-Segel (FLKS) system is a macroscopic model describing bacteria motion by chemotaxis which takes into account saturation of the velocity. The hyper-bolic form and some special parabolic forms have been derived from kinetic equations describing the run and tumble process for bacterial motion. The FLKS model also has the advantage that traveling pulse solutions exist as observed experimentally. It has attracted the attention of many authors recently. We design and prove a general derivation of the FLKS departing from a kinetic model under stiffness assumption of the chemot…
We consider the boundary value problem $-Δu + u =λe^u$ in $Ω$ with Neumann boundary condition, where $Ω$ is a bounded smooth domain in $\mathbb R^2$, $λ>0.$ This problem is equivalent to the stationary Keller-Segel system from chemotaxis. We establish the existence of a solution $u_λ$ which exhibits a sharp boundary layer along the entire boundary $\partialΩ$ as $λ\to 0$. These solutions have large mass in the sense that $ \int_Ωλe^{u_λ} \sim |\logλ|.$
We consider a coupled system consisting of the Navier-Stokes equations and a porous medium type of Keller-Segel system that model the motion of swimming bacteria living in fluid and consuming oxygen. We establish the global-in-time existence of weak solutions for the Cauchy problem of the system in dimension three. In addition, if the Stokes system, instead Navier-Stokes system, is considered for the fluid equation, we prove that bounded weak solutions exist globally in time.
We give a simple proof, relying on a {\it two-particles} moment computation, that there exists a global weak solution to the $2$-dimensional parabolic-elliptic Keller-Segel equation when starting from any initial measure $f_0$ such that $f_0(\mathbb{R}^2)< 8 π$.
In this paper we consider a one-dimensional fully parabolic quasilinear Keller-Segel system with critical nonlinear diffusion. We show uniform-in-time boundedness of solutions, which means, that unlike in higher dimensions, there is no critical mass phenomenon in the case of critical diffusion. To this end we utilize estimates from a well-known Lyapunov functional and a recently introduced new Lyapunov-like functional in [3].
In this paper, we proposed a coupled Patlak-Keller-Segel-Navier-Stokes system, which has dissipative free energy. On the plane $\rr^2$, if the total mass of the cells is strictly less than $8π$, classical solutions exist for any finite time, and their $H^s$-Sobolev norms are almost uniformly bounded in time. For the radially symmetric solutions, this $8π$-mass threshold is critical. On the torus $\mathbb{T}^2$, the solutions are uniformly bounded in time under the same mass constraint.
This paper is concerned with the global boundedness and blowup of solutions to the Keller-Segel system with density-dependent motility in a two-dimensional bounded smooth domain with Neumman boundary conditions. We show that if the motility function decays exponentially, then a critical mass phenomenon similar to the minimal Keller-Segel model will arise. That is there is a number $m_*>0$, such that the solution will globally exist with uniform-in-time bound if the initial cell mass (i.e. $L^1$-norm of the initial value of cell density) is less than $m_*$, while the solution may blow up if the…
The existence of weak solutions and upper bounds for the blow-up time for time-discrete parabolic-elliptic Keller-Segel models for chemotaxis in the two-dimensional whole space are proved. For various time discretizations, including the implicit Euler, BDF, and Runge-Kutta methods, the same bounds for the blow-up time as in the continuous case are derived by discrete versions of the virial argument. The theoretical results are illustrated by numerical simulations using an upwind finite-element method combined with second-order time discretizations.
We investigate in this note the dynamics of a one-dimensional Keller-Segel type model on the half-line. On the contrary to the classical configuration, the chemical production term is located on the boundary. We prove, under suitable assumptions, the following dichotomy which is reminiscent of the two-dimensional Keller-Segel system. Solutions are global if the mass is below the critical mass, they blow-up in finite time above the critical mass, and they converge to some equilibrium at the critical mass. Entropy techniques are presented which aim at providing quantitative convergence results f…
In this paper, we study the global stability of classical solutions to a Keller--Segel equations in scaling-invariant spaces. We prove that for any given $0<\mathcal{M}<1+λ_1$ with $λ_1$ being the first eigenvalue of Neumann Laplacian, the initial--boundary value problem of the Keller--Segel system has a unique globally bounded classical solution provided that the initial datum is chosen sufficiently close to $(\mathcal{M},\mathcal{M})$ in the norm of $L^{d/2}(Ω)\times \dot{W}^{1,d}(Ω)$ and satisfies a natral average mass condition. Our proof is based on the perturbation theory of semigroups a…
This note is devoted to several inequalities deduced from a special form of the logarithmic Hardy-Littlewood-Sobolev, which is well adapted to the characterization of stationary solutions of a Keller-Segel system written in self-similar variables, in case of a subcritical mass. For the corresponding evolution problem, such functional inequalities play an important role for identifying the rate of convergence of the solutions towards the stationary solution with same mass.
Starting from the quantitative stability result of Bianchi and Egnell for the 2-Sobolev inequality, we deduce several different stability results for a Gagliardo-Nirenberg-Sobolev inequality in the plane. Then, exploiting the connection between this inequality and a fast diffusion equation, we get a quantitative stability for the Log-HLS inequality. Finally, using all these estimates, we prove a quantitative convergence result for the critical mass Keller-Segel system.
