DNA配体存在下核小体滑动的随机模型
Stochastic model for nucleosome sliding in the presence of DNA ligands
摘要：
核小体沿DNA的热诱导迁移是一种实验研究得很好的现象。最近的实验表明，在小沟结合DNA配体的存在下，重新定位被修改。在这里，我们提出了一个随机的三态模型的核小体沿DNA在这样的配体的存在下的扩散。它使我们能够用解析的方法来描述这种运动的动力学和稳态。利用该模型，我们研究了核小体对外力的响应以及配体的存在对核小体响应的影响。
英文摘要：
Heat-induced mobility of nucleosomes along DNA is an experimentally well-studied phenomenon. A recent experiment shows that the repositioning is modified in the presence of minor-groove binding DNA ligands. We present here a stochastic three-state model for the diffusion of a nucleosome along DNA in the presence of such ligands. It allows us to describe the dynamics and the steady state of such a motion analytically. The analytical results are in excellent agreement with numerical simulations of this stochastic process.With this model, we study the response of a nucleosome to an external force and how it is affected by the presence of ligands.
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