天然未折叠蛋白质的数量与基因组大小成比例
Number of natively unfolded proteins scales with genome size
摘要：
天然未折叠的蛋白质作为柔性构象的集合体存在，其多肽链的大部分缺乏明确的三级结构。尽管缺乏稳定的构型，但它们参与重要的细胞过程。在这项工作中，我们使用了来自蛋白质序列的平均包装和平均接触能的分析以及来自疾病预测因子VSLI 2的三个折叠状态指标，并将它们组合成共识评分，以识别来自细菌、细菌和真核生物的几个基因组中的天然未折叠蛋白质。我们发现预测的天然未折叠蛋白质的数量与基因组中蛋白质的数量之间存在高度相关性。更具体地说，天然未折叠蛋白质的数量与基因组中蛋白质的数量成比例，指数为1.81 ± 0.10。这种比例定律对于理解天然未折叠蛋白质的数量与它们在细胞过程中的作用之间的关系可能很重要。
英文摘要：
Natively unfolded proteins exist as an ensemble of flexible conformations lacking a well defined tertiary structure along a large portion of their polypeptide chain. Despite the absence of a stable configuration, they are involved in important cellular processes. In this work we used from three indicators of folding status, derived from the analysis of mean packing and mean contact energy of a protein sequence as well as from VSL2, a disorder predictor, and we combined them into a consensus score to identify natively unfolded proteins in several genomes from Archaea, Bacteria and Eukarya. We found a high correlation among the number of predicted natively unfolded proteins and the number of proteins in the genomes. More specifically, the number of natively unfolded proteins scaled with the number of proteins in the genomes, with exponent 1.81 +- 0.10. This scaling law may be important to understand the relation between the number of natively unfolded proteins and their roles in cellular processes.
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