生物动力系统的一致性原理
Consistency Principle in Biological Dynamical Systems
摘要：
我们提出了生物系统不同层次之间的一致性原则。鉴于分子复制和细胞繁殖之间的一致性，细胞化学丰度的普遍统计规律推导和实验证实。它们包括基因表达的幂律分布、细胞化学丰度在细胞上的对数正态分布以及幂律嵌入到网络连接分布中。其次，基因型和表型之间的一致性，表型波动的遗传变异和同基因表型波动的发展噪音之间的一般关系。第三，我们讨论了干细胞分化的混沌机制与自主调节，导致细胞繁殖和细胞系生长之间的一致性。
英文摘要：
We propose a principle of consistency between different hierarchical levels of biological systems. Given a consistency between molecule replication and cell reproduction, universal statistical laws on cellular chemical abundances are derived and confirmed experimentally. They include a power law distribution of gene expressions, a lognormal distribution of cellular chemical abundances over cells, and embedding of the power law into the network connectivity distribution. Second, given a consistency between genotype and phenotype, a general relationship between phenotype fluctuations by genetic variation and isogenic phenotypic fluctuation by developmental noise is derived. Third, we discuss the chaos mechanism for stem cell differentiation with autonomous regulation, resulting from a consistency between cell reproduction and growth of the cell ensemble.
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