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arXiv 0807.0749math.PR
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Galton-Watson过程中细胞衰老的检测

Detection of cellular aging in a Galton-Watson process

Jean-François Delmas, Laurence Marsalle

摘要:

我们考虑由Guyon引入的分叉马尔可夫链模型来从细胞谱系检测细胞衰老。考虑到细胞死亡的可能性,我们使用一个潜在的Galton-Watson过程来描述细胞谱系的进化。在这个更一般的框架中,我们给出了一个弱大数定律,一个不变原理,从而波动的平均结果超过一代或一代。我们还证明了每一代的波动是独立的。然后,我们提出了自然修改的测试中给出的Guyon在细胞老化检测的自回归模型的特定情况下。

英文摘要:

We consider the bifurcating Markov chain model introduced by Guyon to detect cellular aging from cell lineage. To take into account the possibility for a cell to die, we use an underlying Galton-Watson process to describe the evolution of the cell lineage. We give in this more general framework a weak law of large number, an invariance principle and thus fluctuation results for the average over one generation or up to one generation. We also prove the fluctuations over each generation are independent. Then we present the natural modifications of the tests given by Guyon in cellular aging detection within the particular case of the auto-regressive model.

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