原子生物学、静电学和离子通道
Atomic Biology, Electrostatics, and Ionic Channels
摘要：
我相信，如果我们要设计和理解蛋白质，以及定义，制造和使用它们，就需要原子生物学来补充当今的分子生物学。论文的主题是分子生物学和原子生物学。明渠中的电扩散。混合电解质中的电扩散。渗透模型。渗透的状态模型与电场不一致。做原子生物学的模型。分子动力学。时间限制;空间限制;周期性边界条件。明渠模型的层次结构。通道的随机运动。朗之万动力公司反应路径的模拟：Permion。化学反应。怎么了？回到等级制度：奥卡姆剃刀可以割断你的喉咙。Poisson-Nernst-Planck PNP模型通量比;场耦合泵浦。在一种构象的通道中进行门控。场开关选通;选通电流;分支通道选通;阻塞。回到层次结构：链接级别。有什么理论吗？在什么水平上进行调整？简单、进化和自然功能。
英文摘要：
I believe an atomic biology is needed to supplement present day molecular biology, if we are to design and understand proteins, as well as define, make, and use them. Topics in the paper are molecular biology and atomic biology. Electrodiffusion in the open channel. Electrodiffusion in mixed electrolytes. Models of permeation. State Models of Permeation are Inconsistent with the Electric Field. Making models in atomic biology. Molecular dynamics. Temporal Limitations; Spatial Limitations; Periodic boundary conditions. Hierarchy of models of the open channel. Stochastic Motion of the Channel. Langevin Dynamics. Simulations of the Reaction Path: the Permion. Chemical reactions. What was wrong? Back to the hierarchy: Occam's razor can slit your throat. Poisson-Nernst-Planck PNP Models Flux Ratios; Pumping by Field Coupling. Gating in channels of one conformation. Gating by Field Switching; Gating Current; Gating in Branched Channels; Blocking. Back to the hierarchy: Linking levels. Is there a theory? At what level will the adaptation be found? Simplicity, evolution, and natural function.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
