颈连接体对接与驱动蛋白运动的相关性
The relevance of neck linker docking in the motility of kinesin
摘要：
传统的驱动蛋白是一种运动蛋白，它能够沿着微管蛋白质。驱动蛋白的步进运动和力产生的确切机制仍然很不清楚。在本文中，我们认为，颈部连接器对接是这种机制的一个关键因素，没有它的实验观察到的停留时间的步骤不能解释在很大范围内的负载力。我们还表明，实验数据施加非常严格的约束的长度的颈部连接器和它的对接部分，这是兼容的驱动蛋白的已知结构。
英文摘要：
Conventional kinesin is a motor protein, which is able to walk along a microtubule processively. The exact mechanism of the stepping motion and force generation of kinesin is still far from clear. In this paper we argue that neck linker docking is a crucial element of this mechanism, without which the experimentally observed dwell times of the steps could not be explained under a wide range of loading forces. We also show that the experimental data impose very strict constraints on the lengths of both the neck linker and its docking section, which are compatible with the known structure of kinesin.
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