细菌视紫红质单分子膜的电荷传输：构象变化对电流-电压特性的贡献
Charge transport in bacteriorhodopsin monolayers: The contribution of conformational change to current-voltage characteristics
摘要：
当从天然移动到光激活的细菌视紫红质时，由电导增加组成的电荷传输的修饰与蛋白质构象变化相关。一个理论模型的基础上的蛋白质的三级结构到一个电阻网络的地图来实现占通过相邻的氨基酸的电荷转移的顺序隧穿机制。通过与电流-电压实验的比较，验证了该模型的有效性。该模型的可预测性进一步测试牛视紫红质，G-蛋白偶联受体（GPCR）也对光敏感。在这种情况下，结果显示出相反的行为，在光的存在下电导降低。
英文摘要：
When moving from native to light activated bacteriorhodopsin, modification of charge transport consisting of an increase of conductance is correlated to the protein conformational change. A theoretical model based on a map of the protein tertiary structure into a resistor network is implemented to account for a sequential tunneling mechanism of charge transfer through neighbouring amino acids. The model is validated by comparison with current-voltage experiments. The predictability of the model is further tested on bovine rhodopsin, a G-protein coupled receptor (GPCR) also sensitive to light. In this case, results show an opposite behaviour with a decrease of conductance in the presence of light.
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