蛋白酶体转位速率的逆向工程
Reverse Engineering of Proteasomal Translocation Rates
摘要：
我们解决的问题，蛋白酶体蛋白易位，并介绍了一个新的随机模型的蛋白酶体消化（切割）的蛋白质。在这个模型中，我们占的蛋白质易位和定位的切割位点的蛋白酶体从第一原则。我们通过测试实例和处理实验数据表明，我们的模型允许从消化模式的质谱数据重建易位和裂解率，并可用于研究不同实验装置中的运输特性。该模型的详细研究将使蛋白酶体活性的理论定量预测成为可能。
英文摘要：
We address the problem of proteasomal protein translocation and introduce a new stochastic model of the proteasomal digestion (cleavage) of proteins. In this model we account for the protein translocation and the positioning of cleavage sites of a proteasome from first principles. We show by test examples and by processing experimental data that our model allows reconstruction of the translocation and cleavage rates from mass spectroscopy data on digestion patterns and can be used to investigate the properties of transport in different experimental set-ups. Detailed investigation with this model will enable theoretical quantitative prediction of the proteasomal activity.
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