定量细胞质中的间歇性转运
Quantifying intermittent transport in cell cytoplasm
摘要：
主动细胞转运是蛋白质和囊泡递送、细胞周期和分子降解的基本机制。病毒可以劫持运输系统并利用它到达细胞核。大多数传输过程由间歇动力学组成，其中粒子（如病毒）的运动在纯布朗运动和沿着微管的定向运动之间交替。在这篇文章中，我们估计了颗粒附着到微管网络的平均时间。这种计算导致一个粗粒度的径向和圆柱形几何形状的间歇运动方程。最后，通过使用细胞质内的降解活性，我们得到了精确的渐近估计的概率和平均时间的病毒到达一个小的核孔。
英文摘要：
Active cellular transport is a fundamental mechanism for protein and vesicle delivery, cell cycle and molecular degradation. Viruses can hijack the transport system and use it to reach the nucleus. Most transport processes consist of intermittent dynamics, where the motion of a particle, such as a virus, alternates between pure Brownian and directed movement along microtubules. In this communication, we estimate the mean time for particle to attach to a microtubule network. This computation leads to a coarse grained equation of the intermittent motion in radial and cylindrical geometries. Finally, by using the degradation activity inside the cytoplasm, we obtain refined asymptotic estimations for the probability and the mean time a virus reaches a small nuclear pore.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
