大鼠嗅觉受体I7的拓扑变化和阻抗谱：与牛视紫红质和细菌视紫红质的比较分析
Topological change and impedance spectrum of rat olfactory receptor I7: A comparative analysis with bovine rhodopsin and bacterior
摘要：
我们提出了一个可能的选择嗅觉受体（ORs）的纳米生物传感器的传感组件的理论研究。因此，我们产生的阻抗谱的大鼠OR I7在天然和激活状态，并分析它们的差异。通过这种方式，我们将传感作用引起的蛋白质形态变化与其电阻抗的变化联系起来。通过研究最知名的蛋白质的GPCR家族：牛视紫红质的结果进行了比较。我们的研究表明，形态学的变化伴随着阻抗谱的变化，主要与静态阻抗降低至初始值的约60%相关，与现有的大鼠OR I7实验定性一致。该模型的预测性测试成功的情况下，最近的实验细菌视紫红质。目前的研究结果指出，一类新的纳米生物传感器的基础上的GPCR和其他传感蛋白质的电特性的发展是有前途的。
英文摘要：
We present a theoretical investigation on possible selection of olfactory receptors (ORs) as sensing components of nanobiosensors. Accordingly, we generate the impedance spectra of the rat OR I7 in the native and activated state and analyze their differences. In this way, we connect the protein morphological transformation, caused by the sensing action, with its change of electrical impedance. The results are compared with those obtained by studying the best known protein of the GPCR family: bovine rhodopsin. Our investigations indicate that a change in morphology goes with a change in impedance spectrum mostly associated with a decrease of the static impedance up to about 60 % of the initial value, in qualitative agreement with existing experiments on rat OR I7. The predictiveness of the model is tested successfully for the case of recent experiments on bacteriorhodopsin. The present results point to a promising development of a new class of nanobiosensors based on the electrical properties of GPCR and other sensing proteins.
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