类胡萝卜素的发光二极管共振拉曼光谱研究
Resonance Raman measurements of carotenoids using light emitting diodes
摘要：
我们报告一个紧凑的商业仪器测量皮肤组织中的类胡萝卜素的发展。该仪器使用两个发光二极管（LED）的双波长激发和四个光电倍增管的多通道检测。带通滤波器用于选择激发和检测波长。f/1.3光学系统具有高的光通量和单光子灵敏度，这两者在基于LED的拉曼测量中都是至关重要的。我们采用信号处理技术，补偿探测器漂移和误差。LED拉曼仪器的灵敏度和再现性与基于激光的拉曼光谱仪相比毫不逊色。这款小巧便携的仪器用于人体皮肤中类胡萝卜素分子的非侵入性测量，重复性优于10%。
英文摘要：
We report on the development of a compact commercial instrument for measuring carotenoids in skin tissue. The instrument uses two light emitting diodes (LEDs) for dual-wavelength excitation and four photomultiplier tubes for multichannel detection. Bandpass filters are used to select the excitation and detection wavelengths. The f/1.3 optical system has high optical throughput and single photon sensitivity, both of which are crucial in LED-based Raman measurements. We employ a signal processing technique that compensates for detector drift and error. The sensitivity and reproducibility of the LED Raman instrument compares favorably to laser-based Raman spectrometers. This compact, portable instrument is used for non-invasive measurement of carotenoid molecules in human skin with a repeatability better than 10%.
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