染色质重构对基因激活的动力学校正
Kinetic proofreading of gene activation by chromatin remodeling
摘要：
真核生物中的基因激活涉及组蛋白尾部修饰剂、染色质重塑剂和转录因子的协同作用，其精确的协调目前尚不清楚。我们证明，实验观察到的分子之间的相互作用是符合动力学校对计划。我们的发现可能为真核生物中基于染色质修饰物的组合相互作用的基因调控的定量模型的发展提供基础。
英文摘要：
Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodellers and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers.
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