In this article, the estimation of reliability of a system is discussed $p(y<x)$ when strength, $X$, and stress, $Y$, are two independent exponential distribution with different scale parameters when the available data are type II Censored sample. Different methods for estimating the reliability are applied. The point estimators obtained are maximum likelihood estimator, uniformly minimum variance unbiased estimator, and Bayesian estimators based on conjugate and non informative prior distributions. A comparison of the estimates obtained is performed. Interval estimators of the reliability are also discussed.
Estimation of reliability and hazard rate is one of the most important problems raised in many applications especially in engineering studies as well as human lifetime. In this regard, different methods of estimation have been used. Each method exploits various tools and suffers from problems such as complexity of computations, low precision, and so forth. This study is employed the E-Bayesian method, for estimating the parameter and survival functions of the Weibull Generalized Exponential distribution. The estimators are obtained under squared error and LINEX loss functions under progressive…
Danmarks Tekniske Universitet (DTU)（丹麦技术大学）；Donkey Republic（驴共和公司）
Transport demand is highly dependent on supply, especially for shared transport services where availability is often limited. As observed demand cannot be higher than available supply, historical transport data typically represents a biased, or censored, version of the true underlying demand pattern. Without explicitly accounting for this inherent distinction, predictive models of demand would necessarily represent a biased version of true demand, thus less effectively predicting the needs of service users. To counter this problem, we propose a general method for censorship-aware demand modeli…
The paper addresses the problem of estimation of the model parameters of the logistic exponential distribution based on progressive type-I hybrid censored sample. The maximum likelihood estimates are obtained and computed numerically using Newton-Raphson method. Further, the Bayes estimates are derived under squared error, LINEX and generalized entropy loss functions. Two types (independent and bivariate) of prior distributions are considered for the purpose of Bayesian estimation. It is seen that the Bayes estimates are not of explicit forms.Thus, Lindley's approximation technique is employed…
To achieve the goal of providing the best possible care to each patient, physicians need to customize treatments for patients with the same diagnosis, especially when treating diseases that can progress further and require additional treatments, such as cancer. Making decisions at multiple stages as a disease progresses can be formalized as a dynamic treatment regime (DTR). Most of the existing optimization approaches for estimating dynamic treatment regimes including the popular method of Q-learning were developed in a frequentist context. Recently, a general Bayesian machine learning framewo…
The problem of estimating censored linear regression models with autocorrelated errors arises in many environmental and social studies. The present work proposes a Bayesian approach to estimate censored regression models with AR(p) errors. The algorithm developed here considers the Gibbs sampler with data augmentation(GDA), in which, at each iteration, both the model parameters and the latent variables are sampled. The data augmentation is achieved from multiple sampling of the latent variables from the corresponding conditional distributions. A suitable variable transformation allows the full…
Penalized B-splines are routinely used in additive models to describe smooth changes in a response with quantitative covariates. It is typically done through the conditional mean in the exponential family using generalized additive models with an indirect impact on other conditional moments. Another common strategy consists in focussing on several low-order conditional moments, leaving the complete conditional distribution unspecified. Alternatively, a multi-parameter distribution could be assumed for the response with several of its parameters jointly regressed on covariates using additive ex…
A flexible quantile mixed-effects model for censored outcomes
Syneos Health；Department of Mathematical Statistics and Actuarial Science, University of the Free State（自由州大学数学统计与精算科学系）；I-BioStat, KU Leuven（KU鲁汶大学生物统计研究所）；Department of Statistics and Actuarial Science, University of Stellenbosch（斯泰伦博斯大学统计与精算科学系）
We investigate the problem of estimating the product of means of independent populations from the one parameter exponential family in a Bayesian framework. We give a random design which allocates mi the number of observations from population Pi such that the Bayes risk associated with squared error loss and cost per unit observation is as small as possible. The design is shown to be asymptotically optimal.
This paper focuses on quantifying and estimating the predictive accuracy of prognostic models for time-to-event outcomes with competing events. We consider the time-dependent discrimination and calibration metrics, including the receiver operating characteristics curve and the Brier score, in the context of competing risks. To address censoring, we propose a unified nonparametric estimation framework for both discrimination and calibration measures, by weighting the censored subjects with the conditional probability of the event of interest given the observed data. We demonstrate through simul…
We propose a class of dimension reduction methods for right censored survival data using a counting process representation of the failure process. Semiparametric estimating equations are constructed to estimate the dimension reduction subspace for the failure time model. The proposed method addresses two fundamental limitations of existing approaches. First, using the counting process formulation, it does not require any estimation of the censoring distribution to compensate the bias in estimating the dimension reduction subspace. Second, the nonparametric part in the estimating equations is a…
Forest-based methods have recently gained in popularity for non-parametric treatment effect estimation. Building on this line of work, we introduce causal survival forests, which can be used to estimate heterogeneous treatment effects in a survival and observational setting where outcomes may be right-censored. Our approach relies on orthogonal estimating equations to robustly adjust for both censoring and selection effects under unconfoundedness. In our experiments, we find our approach to perform well relative to a number of baselines.
The study proposes a new decision theoretic sampling plan (DSP) for Type-I and Type-I hybrid censored samples when the lifetimes of individual items are exponentially distributed with a scale parameter. The DSP is based on an estimator of the scale parameter which always exists, unlike the MLE which may not always exist. Using a quadratic loss function and a decision function based on the proposed estimator, a DSP is derived. To obtain the optimum DSP, a finite algorithm is used. Numerical results demonstrate that in terms of the Bayes risk, the optimum DSP is as good as the Bayesian sampling …
Estimating individualized treatment rules is a central task for personalized medicine. [zhao2012estimating] and [zhang2012robust] proposed outcome weighted learning to estimate individualized treatment rules directly through maximizing the expected outcome without modeling the response directly. In this paper, we extend the outcome weighted learning to right censored survival data without requiring either an inverse probability of censoring weighting or a semiparametric modeling of the censoring and failure times as done in [zhao2015doubly]. To accomplish this, we take advantage of the tree ba…
We propose a novel approach for estimating mean survival time in the presence of censored data, in which we divide the population under study into survival-ordered fractions defined by a set of proportions, and compute the mean survival time for each fraction separately. Our approach provides a detailed picture of the distribution of the time variable while preserving the appealing interpretation of the mean. Our measure proves to be of great use in applications, particularly those where we are able to detect differences in mean survival across groups for certain fractions of the population th…
An optimal dynamic treatment regime (DTR) consists of a sequence of decision rules in maximizing long-term benefits, which is applicable for chronic diseases such as HIV infection or cancer. In this paper, we develop a novel angle-based approach to search the optimal DTR under a multicategory treatment framework for survival data. The proposed method targets maximization the conditional survival function of patients following a DTR. In contrast to most existing approaches which are designed to maximize the expected survival time under a binary treatment framework, the proposed method solves th…
Data with uncertain, missing, censored, and correlated values are commonplace in many research fields including astronomy. Unfortunately, such data are often treated in an ad hoc way in the astronomical literature potentially resulting in inconsistent parameter estimates. Furthermore, in a realistic setting, the variables of interest or their errors may have non-normal distributions which complicates the modeling. I present a novel approach to compute the likelihood function for such data sets. This approach employs Gaussian copulas to decouple the correlation structure of variables and their …
Most work in neural networks focuses on estimating the conditional mean of a continuous response variable given a set of covariates.In this article, we consider estimating the conditional distribution function using neural networks for both censored and uncensored data. The algorithm is built upon the data structure particularly constructed for the Cox regression with time-dependent covariates. Without imposing any model assumption, we consider a loss function that is based on the full likelihood where the conditional hazard function is the only unknown nonparametric parameter, for which uncon…
In medical studies, the collected covariates usually contain underlying outliers. For clustered /longitudinal data with censored observations, the traditional Gehan-type estimator is robust to outliers existing in response but sensitive to outliers in the covariate domain, and it also ignores the within-cluster correlations. To take account of within-cluster correlations, varying cluster sizes, and outliers in covariates, we propose weighted Gehan-type estimating functions for parameter estimation in the accelerated failure time model for clustered data. We provide the asymptotic properties of…
The efficient modeling for disorder in a phenomena depends on the chosen score and objective functions. The main parameters in modeling are location, scale and shape. The exponential power distribution known as generalized Gaussian is extensively used in modeling. In real world, the observations are member of different parametric models or disorder in a data set exists. In this study, estimating equations for the parameters of exponential power distribution are derived to have robust and also efficient M-estimators when the data set includes disorder or contamination. The robustness property o…
On a penalised likelihood approach for joint modelling of longitudinal covariates and partly interval-censored data -- an application to the Anti-PD1 brain collaboration trial
An R package for specifying and estimating linear latent variable models is presented. The philosophy of the implementation is to separate the model specification from the actual data, which leads to a dynamic and easy way of modeling complex hierarchical structures. Several advanced features are implemented including robust standard errors for clustered correlated data, multigroup analyses, non-linear parameter constraints, inference with incomplete data, maximum likelihood estimation with censored and binary observations, and instrumental variable estimators. In addition an extensive simulat…
Consider estimating the G-formula for the counterfactual mean outcome under a given treatment regime in a longitudinal study. Bang and Robins provided an estimator for this quantity that relies on a sequential regression formulation of this parameter. This approach is doubly robust in that it is consistent if either the outcome regressions or the treatment mechanisms are consistently estimated. We define a stronger notion of double robustness, termed sequential double robustness, for estimators of the longitudinal G-formula. The definition emerges naturally from a more general definition of se…
Analysis of random censored life-time data along with some related stochastic covariables is of great importance in many applied sciences like medical research, population studies and planning etc. The parametric estimation technique commonly used under this set-up is based on the efficient but non-robust likelihood approach. In this paper, we propose a robust parametric estimator for the censored data with stochastic covariates based on the minimum density power divergence approach. The resulting estimator also has competitive efficiency with respect to the maximum likelihood estimator under …
Self-Consistent Equation-guided Neural Networks for Censored Time-to-Event Data
Harvard Pilgrim Health Care Institute（哈佛朝圣者医疗保健研究所）；Harvard Medical School（哈佛医学院）；Harvard School of Public Health（哈佛公共卫生学院）；North Carolina State University（北卡罗来纳州立大学）
The estimation of extreme flood quantiles is challenging due to the relative scarcity of extreme data compared to typical target return periods. Several approaches have been developed over the years to face this challenge, including regional estimation and the use of historical flood data. This paper investigates the combination of both approaches using a multivariate peaks-over-threshold model, that allows estimating altogether the intersite dependence structure and the marginal distributions at each site. The joint distribution of extremes at several sites is constructed using a semi-paramet…
Let F be an unknown univariate distribution function to be estimated from a sample containing censored observations and tau be in dom(F). The author has derived a novel nonparametric estimator F_hat for F without making any assumptions regarding the nature of the censoring mechanism or the distribution function F. The distribution of F_hat(tau) can be easily and accurately estimated even for small sample sizes. The estimator F_hat has significantly outperformed the Kaplan Meier estimator in a simulation study with an exponential and a lognormal distribution functions F and a censoring mechanis…
This paper develops robust confidence intervals in high-dimensional and left-censored regression. Type-I censored regression models are extremely common in practice, where a competing event makes the variable of interest unobservable. However, techniques developed for entirely observed data do not directly apply to the censored observations. In this paper, we develop smoothed estimating equations that augment the de-biasing method, such that the resulting estimator is adaptive to censoring and is more robust to the misspecification of the error distribution. We propose a unified class of robus…
We consider the distribution of the turning point location of time series modeled as the sum of deterministic trend plus random noise. If the variables are modeled by shifted exponentials, whose location parameters define the trend, we provide a formula for computing the distribution of the turning point location and consequently to estimate a confidence interval for the location. We test this formula in simulated data series having a trend with asymmetric minimum, investigating the coverage rate as a function of a bandwidth parameter. The method is applied to estimate the confidence interval …
An Accurate Standard Error Estimation for Quadratic Exponential Logistic Regressions by Applying Generalized Estimating Equations to Pseudo-Likelihoods
Two problems that arise in making causal inferences for non-mortality outcomes such as bronchopulmonary dysplasia (BPD) are unmeasured confounding and censoring by death, i.e., the outcome is only observed when subjects survive. In randomized experiments with noncompliance, instrumental variable methods can be used to control for the unmeasured confounding without censoring by death. But when there is censoring by death, the average causal treatment effect cannot be identified under usual assumptions, but can be studied for a specific subpopulation by using sensitivity analysis with additional…
In many medical studies, an ultimate failure event such as death is likely to be affected by the occurrence and timing of other intermediate clinical events. Both event times are subject to censoring by loss-to-follow-up but the nonterminal event may further be censored by the occurrence of the primary outcome, but not vice versa. To study the effect of an intervention on both events, the intermediate event may be viewed as a mediator, but conventional definition of direct and indirect effects is not applicable due to semi-competing risks data structure. We define three principal strata based …
In this paper we develop a statistical estimation technique to recover the transition kernel $P$ of a Markov chain $X=(X_m)_{m \in \mathbb N}$ in presence of censored data. We consider the situation where only a sub-sequence of $X$ is available and the time gaps between the observations are iid random variables. Under the assumption that neither the time gaps nor their distribution are known, we provide an estimation method which applies when some transitions in the initial Markov chain $X$ are known to be unfeasible. A consistent estimator of $P$ is derived in closed form as a solution of a m…
Nonparametric estimation of a state entry time distribution conditional on a "past" state occupation in a progressive multistate model with current status data
We propose a new approach for estimating the parameters of a probability distribution. It consists on combining two new methods of estimation. The first is based on the definition of a new distance measuring the difference between variations of two distributions on a finite number of points from their support and on using this measure for estimation purposes by the method of minimum distance. For the second method, given an empirical discrete distribution, we build up an auxiliary discrete theoretical distribution having the same support of the first and depending on the same parameters of the…
This paper provides a mixture modeling framework using the bivariate generalized exponential distribution. We study different properties of this mixture distribution. Hierarchical EM algorithm is developed for finding the estimates of the parameters. The algorithm takes very large sample size to work as it contains many stages of approximation. Numerical Results are provided for more illustration.
Current status data are commonly encountered in medical and epidemiological studies in which the failure time for study units is the outcome variable of interest. Data of this form are characterized by the fact that the failure time is not directly observed but rather is known relative to an observation time; i.e., the failure times are either left- or right-censored. Due to its structure, the analysis of such data can be challenging. To circumvent these challenges and to provide for a flexible modeling construct which can be used to analyze current status data, herein, a partially linear addi…
