免疫监视下的时空噪声触发浸润性肿瘤生长
Spatiotemporal Noise Triggering Infiltrative Tumor Growth under Immune Surveillance
摘要：
假设时空噪声反映了空间扩展的肿瘤系统中的环境波动。本文首次引入结构因子来定量描述肿瘤的侵袭性生长。均匀的环境可导致肿瘤细胞的膨胀性生长，而不均匀的环境是浸润性生长的基础。上述两种情况下的不同响应由时空噪声的特征临界强度分开。理论和数值结果对临床图像给出了一个密切的注释。
英文摘要：
A spatiotemporal noise is assumed to reflect the environmental fluctuation in a spatially extended tumor system. We introduce firstly the structure factor to reveal the invasive tumor growth quantitatively. The homogenous environment can lead to an expansive growth of the tumor cells, while the inhomogenous environment underlies an infiltrative growth. The different responses of above two cases are separated by a characteristic critical intensity of the spatiotemporal noise. Theoretical and numerical results present a close annotation to the clinical images.
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