基于DNA的柔性哑铃结构的磁泳效应
Magnetophoresis of Flexible DNA-based Dumbbell Structures
摘要：
利用磁力对磁性微结构和纳米结构的控制运动和操纵可以在生物医学、诊断学和免疫学中产生重要的应用。我们报告控制磁泳和拉伸，在水溶液中，含有磁性和抗磁性微球的DNA为基础的哑铃结构。实验测量哑铃的速度和拉伸，并与基于作用在单个磁珠或整个哑铃结构上的力的理论模型相关联。结果表明，哑铃结构的精确和可预测的操作是可以实现的，并可能被应用于免疫磁性细胞分离器。
英文摘要：
Controlled movement and manipulation of magnetic micro and nanostructures using magnetic forces can give rise to important applications in biomedecine, diagnostics and immunology. We report controlled magnetophoresis and stretching, in aqueous solution, of a DNA-based dumbbell structure containing magnetic and diamagnetic microspheres. The velocity and stretching of the dumbbell were experimentally measured and correlated with a theoretical model based on the forces acting on individual magnetic beads or the entire dumbbell structures. The results show that precise and predictable manipulation of dumbbell structures is achievable and can potentially be applied to immunomagnetic cell separators.
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