用于近距离放射治疗的MRI/TRUS数据融合
MRI/TRUS data fusion for brachytherapy
摘要：
背景：前列腺近距离放射治疗包括在经直肠超声成像（TRUS）控制下放置放射性粒子以破坏肿瘤。它需要从图像中描绘前列腺以进行剂量计划。由于超声成像依赖于患者和操作者，因此我们建议将MRI数据融合到TRUS数据，以使图像处理更可靠。已经对这种方法的技术准确性进行了评估。方法：我们目前正在进行的工作，从剂量学的角度评价的方法。目的是确定该系统可能对患者治疗产生的影响。根据初始TRUS前列腺轮廓进行剂量规划，并在通过数据融合修改的轮廓上进行评价。研究结果：对于纳入的8例患者，我们证明TRUS前列腺体积最常被低估，剂量以相关方式被高估。然而，仍验证了这8例患者的剂量限制。结论：这证实了我们最初的假设。
英文摘要：
BACKGROUND: Prostate brachytherapy consists in placing radioactive seeds for tumour destruction under transrectal ultrasound imaging (TRUS) control. It requires prostate delineation from the images for dose planning. Because ultrasound imaging is patient- and operator-dependent, we have proposed to fuse MRI data to TRUS data to make image processing more reliable. The technical accuracy of this approach has already been evaluated. METHODS: We present work in progress concerning the evaluation of the approach from the dosimetry viewpoint. The objective is to determine what impact this system may have on the treatment of the patient. Dose planning is performed from initial TRUS prostate contours and evaluated on contours modified by data fusion. RESULTS: For the eight patients included, we demonstrate that TRUS prostate volume is most often underestimated and that dose is overestimated in a correlated way. However, dose constraints are still verified for those eight patients. CONCLUSIONS: This confirms our initial hypothesis.
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