核小体转换
Nucleosome Switching
摘要：
我们提出了一个定位的核小体沿酵母DNA的染色体之一的结合潜力和核小体的化学势的强度的函数的物理力学分析。我们发现一个显着的密度的两个级别的核小体开关区域，作为化学势的函数，核小体分布经历了一个“微”的一级过渡。这些核小体开关的位置与转录因子结合位点的位置有很强的相关性。
英文摘要：
We present a statistical-mechanical analysis of the positioning of nucleosomes along one of the chromosomes of yeast DNA as a function of the strength of the binding potential and of the chemical potential of the nucleosomes. We find a significant density of two-level nucleosome switching regions where, as a function of the chemical potential, the nucleosome distribution undergoes a "micro" first-order transition. The location of these nucleosome switches shows a strong correlation with the location of transcription-factor binding sites.
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