调节性分化作为相互作用细胞群的分支
Regulative Differentiation as Bifurcation of Interacting Cell Population
摘要：
在多细胞生物中，几种细胞状态共存。为了确定每种细胞类型，除了细胞内基因表达动力学之外，细胞-细胞相互作用通常是必需的。基于动力系统理论，我们提出了一个机制，细胞分化与调节人口的每种细胞类型，采取简单的细胞模型与基因表达动力学。通过结合几个相互作用动力学，我们发现，细胞模型与一个单一的细胞内正反馈回路表现出细胞命运开关，与细胞总数的变化。根据细胞-细胞相互作用的形式，针对细胞总数的变化，保持给定细胞类型的数量或每种细胞类型的群体比例。分化是细胞状态通过细胞间相互作用分叉的结果，而种群调节则通过细胞间相互作用分叉参数的自洽确定来解释。这种机制的相关性，在几个多细胞系统的发展和分化进行了讨论。
英文摘要：
In multicellular organisms, several cell states coexist. For determining each cell type, cell-cell interactions are often essential, in addition to intracellular gene expression dynamics. Based on dynamical systems theory, we propose a mechanism for cell differentiation with regulation of populations of each cell type by taking simple cell models with gene expression dynamics. By incorporating several interaction kinetics, we found that the cell models with a single intracellular positive-feedback loop exhibit a cell fate switching, with a change in the total number of cells. The number of a given cell type or the population ratio of each cell type is preserved against the change in the total number of cells, depending on the form of cell-cell interaction. The differentiation is a result of bifurcation of cell states via the intercellular interactions, while the population regulation is explained by self-consistent determination of the bifurcation parameter through cell-cell interactions. The relevance of this mechanism to development and differentiation in several multicellular systems is discussed.
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