小鼠表皮维持机制：细胞分裂和Voter模型
Mechanism of murine epidermal maintenance: Cell division and the Voter Model
摘要：
本文介绍了一个有趣的实验的例子，选民模型统计在生物学。在最近的工作小鼠尾部皮肤，增殖细胞被限制在一个二维层，我们表明，细胞增殖和分化根据一个简单的随机模型的细胞分裂，涉及只有一种类型的增殖细胞，可能会分裂对称和不对称。奇怪的是，这些简单的规则提供了对细胞群体动态的极好预测，而不必解决它们的空间分布。然而，如果通过允许细胞随机扩散来解决细胞的空间行为，那么可以推断密度波动会破坏组织融合，这意味着物理系统中存在某种隐藏的空间调节。为了推断空间调控的机制，我们考虑了一个二维模型的细胞命运，保留了整体的人口动态。通过确定所产生的行为与三个物种的变化的“选民”模型，我们预测，增殖细胞在基底层应该集群。对增殖活性染色的细胞的经验相关性的分析证实，预期的聚类行为确实在自然界中可见。
英文摘要：
This paper presents an interesting experimental example of voter-model statistics in biology. In recent work on mouse tail-skin, where proliferating cells are confined to a two-dimensional layer, we showed that cells proliferate and differentiate according to a simple stochastic model of cell division involving just one type of proliferating cell that may divide both symmetrically and asymmetrically. Curiously, these simple rules provide excellent predictions of the cell population dynamics without having to address their spatial distribution. Yet, if the spatial behaviour of cells is addressed by allowing cells to diffuse at random, one deduces that density fluctuations destroy tissue confluence, implying some hidden degree of spatial regulation in the physical system. To infer the mechanism of spatial regulation, we consider a two-dimensional model of cell fate that preserves the overall population dynamics. By identifying the resulting behaviour with a three-species variation of the "Voter" model, we predict that proliferating cells in the basal layer should cluster. Analysis of empirical correlations of cells stained for proliferation activity confirms that the expected clustering behaviour is indeed seen in nature.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
