脑内病变扩散与控制的仿真研究
Simulation of Spread and Control of Lesions in Brain
摘要：
使用中枢神经系统（CNS）的平面网络（图）表示构建了用于脑中病变的传播和控制的仿真模型。该模型的灵感来自于在多发性硬化症（MS）（一种慢性CNS疾病）的情况下观察到的病变结构。最初的损伤部位位于单位正方形的中心，并根据网络边缘（轴突）受损的成功率向外扩散。受损的边缘发出警报信号，在适当的强度水平下，产生程序性细胞死亡。根据程序性细胞死亡的程度和时间，病变可能会得到控制或恶化，类似于通过燃烧周边植被来控制野火。模型的参数相空间表现出从不受控状态到受控状态的平滑过渡。模拟结果表明，该模型能够产生各种各样的病变生长和逮捕的情况。
英文摘要：
A simulation model for the spread and control of lesions in the brain is constructed using a planar network (graph) representation for the Central Nervous System (CNS). The model is inspired by the lesion structures observed in the case of Multiple Sclerosis (MS), a chronic disease of the CNS. The initial lesion site is at the center of a unit square and spreads outwards based on the success rate in damaging edges (axons) of the network. The damaged edges send out alarm signals which, at appropriate intensity levels, generate programmed cell death. Depending on the extent and timing of the programmed cell death, the lesion may get controlled or aggravated akin to the control of wild fires by burning of peripheral vegetation. The parameter phase space of the model shows smooth transition from uncontrolled situation to controlled situation. The simulations show that the model is capable of generating a wide variety of lesion growth and arrest scenarios.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
