点突变对肿瘤抑制基因p53电荷传递特性的影响
Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53
摘要：
我们报告的肿瘤抑制基因p53的DNA序列的电荷转移特性的点突变效应的理论研究。基于有效的单链或双链紧结合模型，模拟空穴沿DNA的传播，与所有可能的点突变的电荷传输调制的统计分析进行。我们发现，与非癌性突变相反，突变热点往往导致显著较弱的{ \em传输特性变化}。这表明，电荷传输可以发挥重要作用的DNA修复缺陷产生的致癌作用。
英文摘要：
We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective single-strand or double-strand tight-binding models which simulate hole propagation along the DNA, a statistical analysis of charge transmission modulations associated with all possible point mutations is performed. We find that in contrast to non-cancerous mutations, mutation hotspots tend to result in significantly weaker {\em changes of transmission properties}. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.
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