转录后调控驱动酵母代谢周期的时间区室化
Post-transcriptional Regulation Drives Temporal Compartmentalization of the Yeast Metabolic Cycle
摘要：
在酵母代谢循环期间，涉及大约一半基因组的稳定周期性的维持需要对基因表达进行非常严格和有效的控制。出于这个原因，代谢循环是一个很好的候选人测试一类转录后调节因子的作用，所谓的PUF家族，其全基因组的mRNA结合特异性最近进行了实验评估。在这里，我们表明，在代谢周期和PUF家族蛋白的mRNA结合特异性的基因表达时间序列的综合计算分析允许一个非常具体的作用，通过选择性的转录后mRNA降解在酵母代谢周期的全球调节的明确演示。
英文摘要：
The maintainance of a stable periodicity during the yeast metabolic cycle involving approximately half of the genome requires a very strict and efficient control of gene expression. For this reason, the metabolic cycle is a very good candidate for testing the role of a class of post-transcriptional regulators, the so called PUF-family, whose genome-wide mRNA binding specificity was recently experimentally assessed. Here we show that an integrated computational analysis of gene expression time series during the metabolic cycle and the mRNA binding specificity of PUF-family proteins allow for a clear demonstration of the very specific role exerted by selective post-transcriptional mRNA degradation in yeast metabolic cycle global regulation.
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