Tight-binding modeling of charge migration in DNA devices
G. Cuniberti, E. Macia, A. Rodriguez, R. A. Römer
备注：
24 PDF pages of Springer SVMult LaTeX (included), ISBN-10: 3540724931, ISBN-13: 978-3540724933
发表信息：
in "Charge Migration in DNA: Perspectives from Physics, Chemistry and Biology" (T. Chakraborty, Ed.), Springer Verlag, Berlin, pp. 1-21 (2007), ISBN: 978-3-540-72493-3
Long range charge transfer experiments in DNA oligomers and the subsequently measured -- and very diverse -- transport response of DNA wires in solid state experiments exemplifies the need for a thorough theoretical understanding of charge migration in DNA-based natural and artificial materials. Here we present a review of tight-binding models for DNA conduction which have the intrinsic merit of containing more structural information than plain rate-equation models while still retaining sufficient detail of the electronic properties. This allows for simulations of transport properties to be more manageable with respect to density functional theory methods or correlated first principle algorithms.
Domesticated P elements in the Drosophila montium species subgroup have a new function related to a DNA binding property
转座因子的分子驯化被定义为宿主基因组对其进行功能性募集。到目前为止，两个独立的事件的分子驯化的P转座因子已被描述：在果蝇obscura种组和果蝇montium种亚组。这些P neogenes由固定的、非重复的序列组成，可能编码66 kDa的阻遏物样蛋白（RL）。在这里，我们调查montium P neogenes的功能。我们提供了两种montium（D。tsacasi和D. bocqueti）在成虫和幼虫的脑和性腺中特异性表达。我们测试的假设，montium P neogenes的功能是有关的远相关的移动P元件共存于基因组中的易位的抑制。我们的研究结果强烈表明，montium P neogenes不招募下调P元件转位。考虑到由移动或固定P同源序列编码的所有蛋白质都显示出DNA结合结构域的强保守性，我们测试了RL蛋白在体内结合DNA的能力。多线染色体的免疫染色。黑腹果蝇转基因系强烈表明，montium P neogenes编码在体内结合DNA的蛋白质。RL蛋白显示出与染色体的多重结合。我们认为，物业招聘的情况下的montium P新蛋白是它们的DNA结合性能。这些新生代的可能功能进行了讨论。
Highly conserved sequence-specific double-stranded DNA binding networks contributing to divergent genomic evolution of human and chimpanzee brain development
Institute of Engineering in Medicine University of California, San Diego（加州大学圣地亚哥分校工程医学院）
In vitro binding energies capture Klf4 occupancy across the human genome
Max Planck Institute of Molecular Cell Biology and Genetics（马克斯·普朗克分子细胞生物学与遗传学研究所）；Max Planck Institute for the Physics of Complex Systems（马克斯·普朗克复杂系统物理研究所）；Center for Systems Biology Dresden（德累斯顿系统生物学中心）；Cluster of Excellence Physics of Life, Technical University Dresden（德累斯顿工业大学生命物理卓越集群）
Identification and characterization of unique to human regulatory sequences in embryonic stem cells reveal associations with transposable elements, distal enhancers, non-coding RNA, and DNA methylation-driven mechanisms of genome editing
The Stanford University School of Medicine（斯坦福大学医学院）；Sanford-Burnham Medical Research Institute（桑福德-伯纳姆医学研究所）；Genlight Technology Corporation（Genlight科技有限公司）
