跨尺度关联生物物理特性
Relating Biophysical Properties Across Scales
摘要：
多细胞生命系统的一个显著特征是它在不同的尺度上运行，从细胞内到生物体。目前对组织水平的性质如何与细胞和亚细胞性质相关知之甚少。现代测量技术提供了细胞内和组织水平的定量结果，但没有这些之间的联系。在目前的工作中，我们概述了一个框架，以解决这一问题。我们特别关注组织融合的形态发生过程，通过两个相邻的多细胞聚集体的合并。这个过程的时间演化可以用粘性流体理论精确描述。我们还通过蒙特卡罗模拟和一种新的细胞粒子动力学（CPD）模型研究了融合，该模型类似于早期引入的亚细胞单元模型（Newman，2005）。使用实验、理论和建模的组合，我们能够将测量的组织水平生物物理量与亚细胞参数相关联。我们的方法具有超越这里考虑的特定形态发生过程的有效性，并提供了一种通用的方法来关联跨尺度的生物物理特性。
英文摘要：
A distinguishing feature of a multicellular living system is that it operates at various scales, from the intracellular to organismal. Very little is known at present on how tissue level properties are related to cell and subcellular properties. Modern measurement techniques provide quantitative results at both the intracellular and tissue level, but not on the connection between these. In the present work we outline a framework to address this connection. We specifically concentrate on the morphogenetic process of tissue fusion, by following the coalescence of two contiguous multicellular aggregates. The time evolution of this process can accurately be described by the theory of viscous liquids. We also study fusion by Monte Carlo simulations and a novel Cellular Particle Dynamics (CPD) model, which is similar to the earlier introduced Subcellular Element Model (Newman, 2005). Using the combination of experiments, theory and modeling we are able to relate the measured tissue level biophysical quantities to subcellular parameters. Our approach has validity beyond the particular morphogenetic process considered here and provides a general way to relate biophysical properties across scales.
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