拟合分析为联合脂质体给药治疗根除HIV/AIDS感染提供了进一步证据
Fitting analysis provides further evidence for eradication of hiv/aids infection under combined liposome drug delivery treatment
摘要:
现在很明显,通过高效抗逆转录病毒疗法(HAART)治疗艾滋病毒/艾滋病的普遍接受的战略不会导致在合理的时间内根除艾滋病毒。这是直接从典型的指数病毒载量衰减治疗后,揭示了初始相当大的,但不完全的减少血浆HIV RNA与随后的低水平的HIV持久性,即使在有效的抗逆转录病毒治疗的患者。在这里,我们表明,病毒载量遵循一个简单的零趋势线性回归线,在不同的治疗方法,我们最近提出的。这明确地表明在合理的时间内彻底根除艾滋病毒。
英文摘要:
It is now evident that the commonly accepted strategy for treatment of HIV/AIDS by highly active antiretroviral therapy (HAART) will not lead to eradication of HIV in a reasonable time. This is straightforward from the typical exponential viral load decay upon treatment revealing initial considerable but incomplete reduction of plasma HIV RNA with subsequent low level HIV persistence even in patients on effective antiretroviral therapy. Here we show that the viral load follows a simple zero trend linear regression line under different treatment approach recently proposed by us. This unambiguously indicates a whole body HIV eradication in reasonable time.
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