真核生物基因调控中的协同作用：一个病毒实例的物理性质
Cooperative action in eukaryotic gene regulation: physical properties of a viral example
摘要：
EB病毒（EBV）感染超过90%的人类，并且是几种严重和轻度疾病的原因。它是一种肿瘤病毒，并已被广泛研究作为一个模型系统的基因（去）调节在人类。EBV生命周期的一个中心特征是它能够以潜伏期I、II和III的状态持续存在于人B细胞中。在潜伏期III中，宿主细胞被驱动进行细胞增殖并因此扩增病毒群体，但不进入裂解途径，并且不产生新的病毒体，而潜伏期I状态几乎完全休眠。在本文中，我们研究了EB病毒潜伏期I和潜伏期III之间的开关的物理化学模型。我们发现，两个竞争的转录因子，一个病毒和一个从主机的结合位点的异常大量的，服务，使开关尖锐（较高的希尔系数），无论是通过合作绑定的分子之间的同一物种时，他们绑定，或通过两个物种之间的竞争，如果有足够的空间位阻。
英文摘要：
The Epstein-Barr virus (EBV) infects more than 90% of the human population, and is the cause of several both serious and mild diseases. It is a tumorivirus, and has been widely studied as a model system for gene (de)regulation in human. A central feature of the EBV life cycle is its ability to persist in human B cells in states denoted latency I, II and III. In latency III the host cell is driven to cell proliferation and hence expansion of the viral population, but does not enter the lytic pathway, and no new virions are produced, while the latency I state is almost completely dormant. In this paper we study a physico-chemical model of the switch between latency I and latency III in EBV. We show that the unusually large number of binding sites of two competing transcription factors, one viral and one from the host, serves to make the switch sharper (higher Hill coefficient), either by cooperative binding between molecules of the same species when they bind, or by competition between the two species if there is sufficient steric hindrance.
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