单角蛋白纤维的纳米力学：α螺旋-> β折叠转变和水效应的拉曼研究
Nanomechanics of single keratin fibres: A Raman study of the alpha helix -> beta sheet transition and water effect
摘要：
通过化学键纳米级探针，使用显微拉曼光谱允许在应变期间区分构象（α螺旋-> β折叠）、链取向、二硫键断开（~ 20%）以及链内和链间距离的增加的变化。显微拉曼光谱和a的组合允许定量测量装载期间肽链中化学键的延伸。研究了在干燥环境（40- 60%相对湿度）和水饱和的情况下，人发应变期间角蛋白的纳米结构转变。水允许链的滑动并降低键能。光谱分析和二维相关分析是两种相干而又独立的跟踪拉曼探针结构变化的方法。纳米力学（拉曼）和微观力学（应变/应力）之间的分析证实了实验结果的有效性，使用的工具和原则，以及与Chapman & Hearle描述的角蛋白纤维的结构模型的协议。
英文摘要：
The use of micro-Raman spectroscopy, through chemical bond nano-scale probes, allows the changes in conformations (alpha helix -> beta sheet), chain orientation, disconnection of disulfide bonds (-20%) and the increase of intra and inter-chain distances during the strain to be distinguished. The combination of micro-Raman spectroscopy and a allows a quantitative measure of the extension of chemical bonds in the peptidic chain during loading. The nano-structural transformations of keratin during the strain of human hair in a dry environment (40-60 % relative humidity) and saturated with water have been studied. The water permits the sliding of the chains and decreases the bond energy hair. Spectral analyses and 2D correlation are two coherent and independent methods to follow change the Raman probes which are sensitive to structural . The between nano-mechanical (Raman) and micro-mechanical (strain/stress) analyses confirms the validity of the experimental results, tools and principles used, as well as the agreement with the structural model of keratin fibres described by Chapman & Hearle.
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