对“代谢网络的调节能力“一文的评论
Comment on "Regularizing capacity of metabolic networks"
摘要:
在最近的一篇论文中,Marr、Muller-Linow和Hutt [Phys.Rev.E75,041917(2007)]研究了代谢网络上的人工动态系统。他们发现,与参考模型的网络相比,这个动态系统在真实网络中的时间演化不那么复杂。作者认为,这表明代谢网络结构是生化稳态稳定性背后的主要因素。我们使用一个动态系统模拟实际反应动力学来重新分析同类数据。从我们的分析中得出的关于稳定性的结论与Marr等人的结论不一致。我们认为,这个问题需要更详细的建模。
英文摘要:
In a recent paper, Marr, Muller-Linow and Hutt [Phys. Rev. E 75, 041917 (2007)] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of reference models. The authors argue that this suggests that metabolic network structure is a major factor behind the stability of biochemical steady states. We reanalyze the same kind of data using a dynamic system modeling actual reaction kinetics. The conclusions about stability, from our analysis, are inconsistent with those of Marr et al. We argue that this issue calls for a more detailed type of modeling.
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