模拟HIV-1病毒粒子和蛋白对Fas诱导的感染细胞凋亡的影响
Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells
摘要：
我们首次报道了HIV蛋白对受感染细胞凋亡途径（依赖半胱天冬酶）的影响的建模和模拟。这项工作是新的，是最近的报告和澄清FAS凋亡途径的文献的延伸。我们从文献中收集了大部分反应速率和初始条件，其余的常数通过将我们的模型拟合到报道的实验结果来计算。使用获得的模型，我们然后运行了被感染的记忆T细胞的模拟，也称为潜伏T细胞，目前，这是找到治愈艾滋病毒的主要障碍。我们现在可以报告说，受感染的潜伏T细胞从重新激活的那一刻起，估计寿命约为42小时。据我们所知，这是第一次从受感染的记忆T细胞中获得这种类型的结果。
英文摘要：
We report a first in modeling and simulation of the effects of the HIV proteins on the (caspase dependent) apoptotic pathway in infected cells. This work is novel and is an extension on the recent reports and clarifications on the FAS apoptotic pathway from the literature. We have gathered most of the reaction rates and initial conditions from the literature, the rest of the constants have been computed by fitting our model to the experimental results reported. Using the model obtained we have then run the simulations for the infected memory T cells, called also latent T cells, which, at the moment, represent the major obstacle to finding a cure for HIV. We can now report that the infected latent T cells have an estimated lifetime of about 42 hours from the moment they are re-activated. As far as we know this is the first result of this type obtained for the infected memory T cells.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
