一氧化二氮麻醉气体溶液的振动红外寿命
Vibrational Infrared Lifetime of the Anesthetic nitrous oxide gas in solution
摘要：
本文报道了麻醉气体一氧化二氮（N $_2$ O）溶于辛醇和橄榄油中的不对称基频伸缩2218 cm $^{-1}$振动的寿命。这些溶剂是常用于评估麻醉剂效力的模型系统。皮秒时间尺度的分子动力学模拟表明，蛋白质动力学或膜动力学在麻醉作用的分子机制中起作用。具有100 fs时间分辨率的超快红外光谱是在这样的时间尺度上探测麻醉剂分子动力学的理想工具。在振动带的峰值处的泵浦-探测研究产生在橄榄油中的$55 \pm 1$ ps和在辛醇中的$52 \pm 1 ps$的寿命。寿命的相似性表明，麻醉剂的能量弛豫主要由环境的疏水性决定，与麻醉剂作用模型一致。结果表明，一氧化二氮是一个很好的模型系统探测麻醉剂-溶剂相互作用的非线性红外光谱。
英文摘要：
The lifetime of the asymmetric fundamental stretching 2218 cm$^{-1}$ vibration of the anesthetic gas nitrous oxide (N$_2$O) dissolved in octanol and olive oil is reported. These solvents are model systems commonly used to assess anesthetic potency. Picosecond time-scale molecular dynamics simulations have suggested that protein dynamics or membrane dynamics play a role in the molecular mechanism of anesthetic action. Ultrafast infrared spectroscopy with 100 fs time resolution is an ideal tool to probe dynamics of anesthetic molecules on such timescales. Pump-probe studies at the peak of the vibrational band yield a lifetime of $55 \pm 1$ ps in olive oil and $52 \pm 1 ps$ in octanol. The similarity of lifetimes suggests that energy relaxation of the anesthetic is determined primarily by the hydrophobic nature of the environment, consistent with models of anesthetic action. The results show that nitrous oxide is a good model system for probing anesthetic-solvent interactions using nonlinear infrared spectroscopy.
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