布尔网络模型预测裂殖酵母细胞周期序列
Boolean network model predicts cell cycle sequence of fission yeast
摘要：
基于已知的生物化学相互作用拓扑结构，建立了裂殖酵母细胞周期调控网络的布尔网络模型.在计算机中模拟该模型，忠实地再现了已知序列的调节活动模式沿细胞周期的活细胞。与现有的微分方程模型相反，除了调节电路的结构之外，没有参数进入模型。该模型的动力学性质表明，生物动力学序列在调控网络中鲁棒地实现，生物定态G1对应于状态空间中的主导吸引子，生物调控序列是一个强吸引轨道.将分裂酵母细胞周期模型与S。cerevisiae中，电路的显着差异，以及动态观察。而后者工作在强阻尼模式，由外部激励驱动，S。Pombe网络表示具有外部阻尼的自激系统。
英文摘要：
A Boolean network model of the cell-cycle regulatory network of fission yeast (Schizosaccharomyces Pombe) is constructed solely on the basis of the known biochemical interaction topology. Simulating the model in the computer, faithfully reproduces the known sequence of regulatory activity patterns along the cell cycle of the living cell. Contrary to existing differential equation models, no parameters enter the model except the structure of the regulatory circuitry. The dynamical properties of the model indicate that the biological dynamical sequence is robustly implemented in the regulatory network, with the biological stationary state G1 corresponding to the dominant attractor in state space, and with the biological regulatory sequence being a strongly attractive trajectory. Comparing the fission yeast cell-cycle model to a similar model of the corresponding network in S. cerevisiae, a remarkable difference in circuitry, as well as dynamics is observed. While the latter operates in a strongly damped mode, driven by external excitation, the S. pombe network represents an auto-excited system with external damping.
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