2606.04994
2026-06-04
cs.LG
q-bio.QM
New Benchmarking Shows Limited Generalization Power of TCR Antigenic Epitope Prediction Models
新基准测试显示TCR抗原表位预测模型的泛化能力有限
Yiming Liao, Yiheng Li, Ning Jiang, Bo Li, Keke Chen
发表机构
*
Trustworthy and Intelligent Computing Lab (TAIC), Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County(可信智能计算实验室(TAIC),计算机科学与电气工程系,马里兰大学巴尔的摩分校)
;
Children’s Hospital of Philadelphia(费城儿童医院)
;
Department of Bioengineering, University of Pennsylvania(生物工程系,宾夕法尼亚大学)
;
Institute for Immunology & Immune Health, University of Pennsylvania(免疫学与免疫健康研究所,宾夕法尼亚大学)
;
Institute for RNA Innovation, University of Pennsylvania(RNA创新研究所,宾夕法尼亚大学)
;
Abramson Cancer Center, University of Pennsylvania(Abramson癌症中心,宾夕法尼亚大学)
;
Center for Precision Engineering for Health, University of Pennsylvania(健康精准工程中心,宾夕法尼亚大学)
;
Center for Cellular Immunotherapies, University of Pennsylvania(细胞免疫治疗中心,宾夕法尼亚大学)
AI总结
本文通过构建两类严格定义的未见基准数据集,评估了T细胞受体(TCR)抗原特异性预测模型的性能,发现现有模型泛化能力有限,并提出了改进框架。