Temporal relation classification is the task of determining the temporal relation between pairs of temporal entities in a text. Despite recent advancements in natural language processing, temporal relation classification remains a considerable challenge. Early attempts framed this task using a comprehensive set of temporal relations between events and temporal expressions. However, due to the task complexity, datasets have been progressively simplified, leading recent approaches to focus on the relations between event pairs and to use only a subset of relations. In this work, we revisit the broader goal of classifying interval relations between temporal entities by considering the full set of relations that can hold between two time intervals. The proposed approach, Interval from Point, involves first classifying the point relations between the endpoints of the temporal entities and then decoding these point relations into an interval relation. Evaluation on the TempEval-3 dataset shows that this approach can yield effective results, achieving a temporal awareness score of $70.1$ percent, a new state-of-the-art on this benchmark.

We evaluate the propensity of frontier models to sabotage or refuse to assist with safety research when deployed as AI research agents within a frontier AI company. We apply two complementary evaluations to four Claude models (Mythos Preview, Opus 4.7 Preview, Opus 4.6, and Sonnet 4.6): an unprompted sabotage evaluation testing model behaviour with opportunities to sabotage safety research, and a sabotage continuation evaluation testing whether models continue to sabotage when placed in trajectories where prior actions have started undermining research. We find no instances of unprompted sabotage across any model, with refusal rates close to zero for Mythos Preview and Opus 4.7 Preview, though all models sometimes only partially completed tasks. In the continuation evaluation, Mythos Preview actively continues sabotage in 7% of cases (versus 3% for Opus 4.6, 4% for Sonnet 4.6, and 0% for Opus 4.7 Preview), and exhibits reasoning-output discrepancy in the majority of these cases, indicating covert sabotage reasoning. Our evaluation framework builds on Petri, an open-source LLM auditing tool, with a custom scaffold running models inside Claude Code, alongside an iterative pipeline for generating realistic sabotage trajectories. We measure both evaluation awareness and a new form of situational awareness termed "prefill awareness", the capability to recognise that prior trajectory content was not self-generated. Opus 4.7 Preview shows notably elevated unprompted evaluation awareness, while prefill awareness remains low across all models. Finally, we discuss limitations including evaluation awareness confounds, limited scenario coverage, and untested pathways to risk beyond safety research sabotage.

In this paper, we report the world's first infrastructure-guided communication-enhanced road crack detection pipeline that is effective and implementable on passenger vehicles. We first design a customized communication protocol to transmit the region of interest from the infrastructure to the vehicle. With proper camera image processing (e.g., dynamic cropping and frame selection), the focused images are provided to the crack detection model. Leveraging state-of-the-art crack detection model backbones and a carefully prepared dataset comprising a forward-facing view with a crack, we train the model to improve crack-detection performance. We demonstrate the full detection pipeline on an experimental vehicle platform, showcase the detection effectiveness, and project future research directions.

ULLER (Unified Language for LEarning and Reasoning) offers a unified first-order logic (FOL) syntax, enabling its knowledge bases to be used directly across a wide range of neurosymbolic systems. The original specification endows this syntax with three pairwise independent semantics: classical, fuzzy, and probabilistic, each accompanied by dedicated semantic rules. We show that these seemingly disparate semantics are all instances of one categorical framework based on monads, the very construct that models side effects in functional programming. This enables the modular addition of new semantics and systematic translations between them. As example, we outline the addition of generalised quantification in Logic Tensor Networks (LTN) to arbitrary (also infinite) domains by extending the Giry monad to probability spaces. In particular, our approach allows a modular implementation of ULLER in Python and Haskell, of which we have published initial versions on GitHub.

The widespread adoption of social media has heightened interest in its psychological effects, particularly on mental health indicators such as anxiety, depression, loneliness, and sleep quality, as these platforms increasingly influence social interactions and well-being. Although previous research has examined correlations between social media use and mental health, few studies have utilized unsupervised machine learning to segment users based on behavioral and psychological patterns, leaving a gap in identifying distinct risk profiles across diverse groups. This study seeks to address this by segmenting individuals according to their social media usage and psychological well-being, employing clustering to reveal hidden patterns and evaluate their mental health implications. Data from 551 participants, collected via an online survey, were preprocessed using KNN imputation for missing values, one-hot encoding for categorical variables like Gender with 5 unique values, and outlier detection via IQR and Z-score methods. K-Means clustering, optimized at 6 clusters using the Elbow Method and a Silhouette Score of 0.32, was applied, with PCA reducing 22 dimensions for visualization and a correlation heatmap highlighting relationships, such as a 0.28 correlation between social media hours and anxiety.

Many sign language translation (SLT) systems operate on pose sequences instead of raw video to reduce input dimensionality, improve portability, and partially anonymize signers. The choice of pose estimator is often treated as an implementation detail, with systems defaulting to widely available tools such as MediaPipe Holistic or OpenPose. We present a systematic comparison of pose estimators for pose-based SLT, covering widely used baselines (MediaPipe Holistic, OpenPose) and newer whole-body/high-capacity models (MMPose WholeBody, OpenPifPaf, AlphaPose, SDPose, Sapiens, SMPLest-X). We quantify downstream impact by training a controlled SLT pipeline on RWTH-PHOENIX-Weather 2014 where only the pose representation varies, evaluating with BLEU and BLEURT. To contextualize translation outcomes, we analyze temporal stability, missing hand keypoints, and robustness to occlusion using higher-resolution videos from the Signsuisse dataset. SDPose and Sapiens achieve the best translation performance (BLEU ~11.5), outperforming the common MediaPipe baseline (BLEU ~10). In occlusion cases, Sapiens is correct in all tested instances (15/15), while OpenPifPaf fails in nearly all (1/15) and also yields the weakest translation scores. Estimators that frequently leave out hand keypoints are associated with lower BLEU/BLEURT. We release code that can be used not only to reproduce our experiments, but also considerably lowers the barrier for other researchers to use alternative pose estimators.

Reverse parking maneuvering of a vehicle with trailer system is a difficult task to complete for human drivers due to the multi-body nature of the system and the unintuitive controls required to orientate the trailer properly. The problem is complicated with the presence of other vehicles that the trailer and its connected vehicle must avoid during the reverse parking maneuver. While path planning methods in reverse motion for vehicles with trailers exist, there is a lack of results that also offer collision avoidance as part of the algorithm. This paper hence proposes a modified Hybrid A*-based algorithm that can accommodate the vehicle-trailer system as well as collision avoidance considerations with the other vehicles and obstacles in the parking environment. One of the novelties of this proposed approach is its adaptability to the vehicle with trailer system, where limits of usable steering input that prevent the occurrence of jackknife incidents vary with respect to system configuration. The other contribution is the addition of the collision avoidance functionality which the standard Hybrid A* algorithm lacks. The method is developed and presented first, followed by simulation case studies to demonstrate the efficacy of the proposed approach.

Vision-language models transfer well in zero-shot settings, but at deployment the visual and textual branches often shift asymmetrically. Under this condition, entropy-based test-time adaptation can sharpen the fused posterior while increasing error, because an unreliable modality may still dominate fusion. We study this failure mode through a majorization view of multimodal posteriors and cast adaptation as a constrained de-mixing problem on the fused prediction. Based on this view, we propose MG-MTTA, which keeps the backbone frozen and updates only a lightweight gate or adapter. The objective combines fused-posterior entropy minimization with a reliability-aware gate prior built from anchor-based modality consistency and cross-modal conflict. Our analysis gives conditions under which entropy reduction preserves the correct ranking and a threshold that characterizes modality-dominance failure. On the ImageNet-based benchmark, MG-MTTA improves top-1 accuracy from 57.97 to 66.51 under semantics-preserving textual shift and from 21.68 to 26.27 under joint visual-textual shift, while remaining competitive in the visual-only benchmark. These results show that multimodal test-time adaptation should control modality reliability, not just prediction entropy.

Technological advancements in cryptocurrency markets have increased accessibility for investors, but concurrently exposed them to the risks of market manipulations. Existing fraud detection mechanisms typically rely on machine learning methods that treat each financial asset (i.e., token) and its related transactions independently. However, market manipulation strategies are rarely isolated events, but are rather characterized by coordination, repetition, and frequent transfers among related assets. This suggests that relational structure constitutes an integral component of the signal and can be effectively represented through graphical means. In this paper, we propose three graph construction methods that rely on aggregated hourly market data. The proposed graphs are processed by a unified spatio-temporal Graph Neural Network (GNN) architecture that combines attention-based spatial aggregation with temporal Transformer encoding. We evaluate our methodology on a real-world dataset comprised of pump-and-dump schemes in cryptocurrency markets, spanning a period of over three years. Our comparative results showcase that our graph-based models achieve significant improvements over standard machine learning baselines in detecting anomalous events. Our work highlights that learned market connectivity provides substantial gains for detecting coordinated market manipulation schemes.

Vision-language models (VLMs) are increasingly proposed as general-purpose tools for scientific data interpretation, yet their reliability on real astronomical observations across diverse modalities remains untested. We present AstroVLBench, a comprehensive benchmark comprising over 4,100 expert-verified instances across five tasks spanning optical imaging, radio interferometry, multi-wavelength photometry, time-domain light curves, and optical spectroscopy. Evaluating six frontier models, we find that performance is strongly modality-dependent: while one model (Gemini 3 Pro) emerges as the most consistently capable across tasks, task-specific strengths vary, and all models substantially underperform domain-specialized methods. Mechanistic ablations reveal that performance depends not only on directing attention to salient visual features but also on grounding those features in physical knowledge. Phenomenological prompts describing what to look for improve accuracy by sharpening model focus, but physical prompts explaining why those features matter perform better overall and yield more balanced classifications with reduced class-specific bias. Consistent with this picture, presenting the underlying one-dimensional measurements directly as numerical tables instead of rendered plots yields up to 13 percentage points improvement. Reasoning quality analysis further demonstrates that, without explicit physical grounding, models may reach correct predictions from phenomenologically plausible cues while providing physically imprecise justifications, establishing that accuracy alone is insufficient for trustworthy scientific deployment. These findings provide the first systematic, multi-modal baselines for VLMs in observational astronomy and identify the specific representation, grounding, and reasoning bottlenecks where current models fail.

Single-image point cloud reconstruction must infer complete 3D geometry, including occluded parts, from a single RGB image. While diffusion-based reconstructors achieve high accuracy, they typically require many denoising iterations, resulting in slow and expensive inference. We propose Point-MF, a Mean-Flow-based framework for low-NFE single-image point cloud reconstruction that couples a Mean-Flow-compatible architecture with an auxiliary loss. Specifically, Point-MF operates directly in point-cloud space to learn the mean velocity field and enables one-step reconstruction with a single network function evaluation (1-NFE), without relying on VAE-based latent representations. To make Mean Flow effective under large interval jumps, Point-MF employs a Diffusion Transformer tailored to the Mean-Flow setting, conditioned on frozen DINOv3 image features via a lightweight token adapter and equipped with explicit interval/time conditioning. Moreover, we introduce Denoised Space Anchor, a set-distance auxiliary loss on the denoised-space estimate $x_θ$ induced by the predicted velocity field, to stabilize large-step generation and reduce outliers and density artifacts. On ShapeNet-R2N2 and Pix3D, Point-MF strikes a strong balance between reconstruction quality and inference speed compared to multi-step diffusion baselines and competitive feedforward models, while generating high-quality point clouds with millisecond-level latency.

Diffusion models are primarily trained for image synthesis, yet their denoising trajectories encode rich, spatially aligned visual priors. In this paper, we demonstrate that these priors can be utilized for text-conditioned semantic and open-vocabulary segmentation, and this approach can be generalized to various downstream tasks to make a general-purpose diffusion segmentation framework. Concretely, we introduce DiGSeg (Diffusion Models as a Generalist Segmentation Learner), which repurposes a pretrained diffusion model into a unified segmentation framework. Our approach encodes the input image and ground-truth mask into the latent space and concatenates them as conditioning signals for the diffusion U-Net. A parallel CLIP-aligned text pathway injects language features across multiple scales, enabling the model to align textual queries with evolving visual representations. This design transforms an off-the-shelf diffusion backbone into a universal interface that produces structured segmentation masks conditioned on both appearance and arbitrary text prompts. Extensive experiments demonstrate state-of-the-art performance on standard semantic segmentation benchmarks, as well as strong open-vocabulary generalization and cross-domain transfer to medical, remote sensing, and agricultural scenarios-without domain-specific architectural customization. These results indicate that modern diffusion backbones can serve as generalist segmentation learners rather than pure generators, narrowing the gap between visual generation and visual understanding.

The Observational Medical Outcomes Partnership Common Data Model (OMOP CDM), maintained by the Observational Health Data Sciences and Informatics (OHDSI) collaboration, enabled the harmonisation of electronic health records data of nearly one billion patients in 83 countries. Yet generating real-world evidence (RWE) from these repositories remains a manual process requiring clinical, epidemiological and technical expertise. LLMs and multi-agent systems have shown promise for clinical tasks, but RWE automation exposes a fundamental challenge: agentic systems introduce emergent behaviours, coordination failures and safety risks that existing approaches fail to govern. No infrastructure exists to ensure agentic RWE generation is flexible, safe and auditable across the lifecycle. We introduce FastOMOP, an open-source multi-agent architecture that addresses this gap by separating three infrastructure layers, governance, observability and orchestration, from pluggable agent-teams. Governance is enforced at the process boundary through deterministic validation independent of agent reasoning, ensuring no compromised or hallucinating agent can bypass safety controls. Agent teams for phenotyping, study design and statistical analysis inherit these guarantees through controlled tool exposure. We validated FastOMOP using a natural-language-to-SQL agent team across three OMOP CDM datasets: synthetic data from Synthea, MIMIC-IV and a real-world NHS dataset from Lancashire Teaching Hospitals (IDRIL). FastOMOP achieved reliability scores of 0.84-0.94 with perfect adversarial and out-of-scope block rates, demonstrating process-boundary governance delivers safety guarantees independent of model choice. These results indicate that the reliability gap in RWE deployment is architectural rather than model capability, and establish FastOMOP as a governed architecture for progressive RWE automation.

Driving in compliance with traffic laws and regulations is a basic requirement for human drivers, yet autonomous vehicles (AVs) can violate these requirements in diverse real-world scenarios. To encode law compliance into AV systems, conventional approaches use formal logic languages to explicitly specify behavioral constraints, but this process is labor-intensive, hard to scale, and costly to maintain. With recent advances in artificial intelligence, it is promising to leverage large language models (LLMs) to derive legal requirements from traffic laws and regulations. However, without explicitly grounding and reasoning in structured traffic scenarios, LLMs often retrieve irrelevant provisions or miss applicable ones, yielding imprecise requirements. To address this, we propose a novel pipeline that grounds LLM reasoning in a traffic scenario taxonomy through node-wise anchors that encode hierarchical semantics. On Chinese traffic laws and OnSite dataset (5,897 scenarios), our method improves law-scenario matching by 29.1\% and increases the accuracy of derived mandatory and prohibitive requirements by 36.9\% and 38.2\%, respectively. We further demonstrate real-world applicability by constructing a law-compliance layer for AV navigation and developing an onboard, real-time compliance monitor for in-field testing, providing a solid foundation for future AV development, deployment, and regulatory oversight.

Chart-to-code generation converts a chart image into an executable plotting script, enabling faithful reproduction and editable visualizations. Existing methods are largely Python-centric, limiting practical use and overlooking a critical source of supervision: the same chart can be expressed by semantically equivalent scripts in different plotting languages. To fill this gap, we introduce Chart2NCode, a dataset of 176K charts paired with aligned scripts in Python, R, and LaTeX that render visually equivalent outputs, constructed via a metadata-to-template pipeline with rendering verification and human quality checks. Building on a LLaVA-style architecture, we further propose CharLuMA, a parameter-efficient adaptation module that augments the multimodal projector with a language-conditioned mixture of low-rank subspaces, allowing the model to share core chart understanding while specializing code generation to the target language through lightweight routing. Extensive experiments show consistent gains in executability and visual fidelity across all languages, outperforming strong open-source baselines and remaining competitive with proprietary systems. Further analyses reveal that balanced multi-language supervision benefits all languages and that the adapter allocates a compact shared core plus language-specific capacity. Codes and data are available at https://github.com/Zhihan72/CharLuMA.

Recent work in hierarchical reinforcement learning has shown success in scaling to billions of timesteps when learning over a set of predefined option reward functions. We show that, instead of using a single reward function per option, the reward functions can be effectively used to induce a space of behaviours, by letting the controller specify linear combinations over reward functions, allowing a more expressive set of policies to be represented. We call this method Hierarchical Behaviour Spaces (HBS). We evaluate HBS on the NetHack Learning Environment, demonstrating strong performance. We conduct a series of experiments and determine that, perhaps going against conventional wisdom, the benefits of hierarchy in our method come from increased exploration rather than long term reasoning.

We consider online learning problems under a partial observability model capturing situations where the information conveyed to the learner is between full information and bandit feedback. In the simplest variant, we assume that in addition to its own loss, the learner also gets to observe losses of some other actions. The revealed losses depend on the learner's action and a directed observation system chosen by the environment. For this setting, we propose the first algorithm that enjoys near-optimal regret guarantees without having to know the observation system before selecting its actions. Along similar lines, we also define a new partial information setting that models online combinatorial optimization problems where the feedback received by the learner is between semi-bandit and full feedback. As the predictions of our first algorithm cannot be always computed efficiently in this setting, we propose another algorithm with similar properties and with the benefit of always being computationally efficient, at the price of a slightly more complicated tuning mechanism. Both algorithms rely on a novel exploration strategy called implicit exploration, which is shown to be more efficient both computationally and information-theoretically than previously studied exploration strategies for the problem.

Coordinating large populations of grid-edge devices requires learning methods that remain fully decentralised in deployment while still respecting three-phase AC distribution-network physics. This paper proposes gradient-based multi-agent proximal learning (GradMAP) to address this challenge. GradMAP trains independent neural-network policies for each agent without any parameter sharing, and each agent uses only its own local observation for online decision-making without communication. During offline training, GradMAP embeds a differentiable three-phase AC power-flow model in a primal-dual learning loop and uses implicit differentiation to propagate exact network-constraint violations to update the policy parameters. To speed up training, GradMAP reuses expensive environment gradients through a proximal surrogate within a trust region defined in the more direct policy-output (action) space, instead of the probability distribution space used in other works, such as PPO. In case studies with 1,000 agents managing batteries, heat pumps, and controllable generators on the IEEE 123-bus feeder, GradMAP learns decentralised policies that minimise three-phase AC load-flow constraint violations within 15 minutes of training on a single workstation-class NVIDIA RTX PRO 5000 Blackwell 48GB GPU. This is a 3--5x training speed-up over gradient-based self-supervised learning benchmarks and substantially better training efficiency than multi-agent reinforcement-learning benchmarks. In out-of-sample tests, GradMAP also delivers among the lowest operating cost and constraint violations.

Progression to dialysis or end-stage renal disease is a rare but clinically important outcome. Clinicians need evidence on how medication exposures influence downstream risk. We constructed a fixed-window EHR cohort (90-day observation, 730-day prediction; N=81401; dialysis/ESRD prevalence: 1.1%) and modeled sequences of diagnoses, procedures, and medications with kidney laboratory trends (creatinine, BUN, eGFR). A transformer-based causal multi-head model was trained to estimate drug- and ingredient-level average treatment effects (ATEs) using counterfactual exposure removal and insertion under a full medication history setup. On test set, predictive performance reached an AUC of 0.694 and PR-AUC of 0.094. At the selected decision threshold (0.883), the model achieved an F1 score of 0.201 with a Brier score of 0.018. Post-hoc causal analyses of lab changes (eGFR, creatinine, BUN) using IPTW, AIPW, naive, and covariate-adjusted OLS methods assessed clinical directionality. Results showed partial protective-direction support for ACE/ARB exposures and worsening-direction signals for loop diuretics.

The increasing reliance on Large Language Models (LLMs) across diverse sectors highlights the need for robust domain-specific and language-specific evaluation datasets; however, the collection of such datasets is challenging due to privacy concerns, regulatory restrictions, and the time cost for manual creation. Existing automated benchmarking methods are often limited by relying on pre-existing data, poor scalability, single-domain focus, and lack of multilingual support. We present STELLAR-E - a fully automated system to generate high-quality synthetic datasets of custom size, using minimal human inputs without depending on existing datasets. The system is structured in two stages: (1) We modify the TGRT Self-Instruct framework to create a synthetic data engine that enables controllable, custom synthetic dataset generation, and (2) an evaluation pipeline incorporating statistical and LLM-based metrics to assess the applicability of the synthetic dataset for LLM-based application evaluations. The synthetic datasets reach an average difference of +5.7% in terms of LLM-as-a-judge scores against existing language-specific benchmarks, demonstrating comparable quality for comprehensive assessment of big and small LLMs. While real datasets remain slightly more challenging for LLMs especially for smaller models, this work establishes a scalable and domain-adaptable benchmarking framework that supports fair evaluation of LLM applications, offering a faster alternative to manual approaches and enabling high-efficiency automated quality assurance cycles.

RGB-Thermal (T) crowd counting aims to integrate visible-spectrum and thermal infrared information to improve the robustness of crowd density estimation in complex scenes. Although existing studies generally improve counting accuracy through cross-modal feature fusion, most current methods rely on implicit cross-modal fusion strategies and lack explicit modeling of local spatial discrepancies as well as fine-grained characterization of modality reliability at the positional level, thereby limiting the accuracy and interpretability of the fusion process. To address these issues, this paper proposes a two-stage fusion framework, RACANet, a Reliability-Aware Crowd Anchor Network for RGB-T crowd counting. First, we introduce a lightweight cross-modal alignment pretraining stage, which explicitly learns cross-modal semantic correspondences through crowd-prior supervision and local bidirectional soft matching. Then, based on the priors learned during pretraining, a Local Anchor Fusion Module (LAFM) is introduced in the formal training stage. This module generates local semantic anchors by aggregating features from highly reliable regions and further enables adaptive pixel-level feature redistribution with a local attention mechanism. In addition, we propose a discrepancy-aware consistency constraint to dynamically coordinate the reliability of regions where modal representations are consistent. Experiments conducted on two widely used benchmark datasets, RGBT-CC and Drone-RGBT, demonstrate that RACANet outperforms existing methods. The anonymous code is available at https://anonymous.4open.science/r/RACANet-9985.

We study the problem of global maximization of a function f given a finite number of evaluations perturbed by noise. We consider a very weak assumption on the function, namely that it is locally smooth (in some precise sense) with respect to some semi-metric, around one of its global maxima. Compared to previous works on bandits in general spaces (Kleinberg et al., 2008; Bubeck et al., 2011a) our algorithm does not require the knowledge of this semi-metric. Our algorithm, StoSOO, follows an optimistic strategy to iteratively construct upper confidence bounds over the hierarchical partitions of the function domain to decide which point to sample next. A finite-time analysis of StoSOO shows that it performs almost as well as the best specifically-tuned algorithms even though the local smoothness of the function is not known.

Large Language Models (LLMs) excel academically but struggle with social intelligence tasks, such as creating good compromises. In this paper, we present methods for generating empathically neutral compromises between two opposing viewpoints. We first compared four different prompt engineering methods using Claude 3 Opus and a dataset of 2,400 contrasting views on shared places. A subset of the gen erated compromises was evaluated for acceptability in a 50-participant study. We found that the best method for generating compromises between two views used external empathic similarity between a compromise and each viewpoint as iterative feedback, outperforming stan dard Chain of Thought (CoT) reasoning. The results indicate that the use of empathic neutrality improves the acceptability of compromises. The dataset of generated compromises was then used to train two smaller foundation models via margin-based alignment of human preferences, improving efficiency and removing the need for empathy estimation during inference.

Many sequential decision-making tasks involve optimizing multiple conflicting objectives, requiring policies that adapt to different user preferences. In multi-objective reinforcement learning (MORL), one widely studied approach} addresses this by training a single policy network conditioned on preference-weighted rewards. In this paper, we explore a novel algorithmic perspective: leveraging reward-free reinforcement learning (RFRL) for MORL. While RFRL has historically been studied independently of MORL, it learns optimal policies for any possible reward function, making it a natural fit for MORL's challenge of handling unknown user preferences. We propose using the RFRL's training objective as an auxiliary task to enhance MORL, enabling more effective knowledge sharing beyond the multi-objective reward function given at training time. To this end, we adapt a state-of-the-art RFRL algorithm to the MORL setting and introduce a preference-guided exploration strategy that focuses learning on relevant parts of the environment. Through extensive experiments and ablation studies, we demonstrate that our approach significantly outperforms the state-of-the-art MORL methods across diverse MO-Gymnasium tasks, achieving superior performance and data efficiency. This work provides the first systematic adaptation of RFRL to MORL, demonstrating its potential as a scalable and empirically effective solution to multi-objective policy learning.

This review proposes an integrative framework grounded on interoception and embodied AI-termed the interoceptive machine framework-that translates biologically inspired principles of internal-state regulation into computational architectures for adaptive autonomy. Interoception, conceived as the monitoring, integration, and regulation of internal signals, has proven relevant for understanding adaptive behavior in biological systems. The proposed framework organizes interoceptive contributions into three functional principles: homeostatic, allostatic, and enactive, each associated with distinct computational roles: internal viability regulation, anticipatory uncertainty-based re-evaluation, and active data generation through interaction. These principles are not intended as direct neurophysiological mappings, but as abstractions that inform the design of artificial agents with improved self-regulation and context-sensitive behavior. By embedding internal state variables and regulatory loops within these principles, AI systems can achieve more robust decision-making, calibrated uncertainty handling, and adaptive interaction strategies, particularly in uncertain and dynamic environments. This approach provides a concrete and testable pathway toward agents capable of functionally grounded self-regulation, with direct implications for human-computer interaction and assistive technologies. Ultimately, the interoceptive machine framework offers a unifying perspective on how internal-state regulation can enhance autonomy, adaptivity, and robustness in embodied AI systems

Clinical fusion of Single Photon Emission Computed Tomography Myocardial Perfusion Imaging (SPECT MPI) and Computed Tomography Angiography (CTA) remains limited by cross-modality misregistration and reliance on manual landmarks, which can hinder accurate ischemia localization and lesion-level functional assessment. To address this issue, we propose a registration and fusion framework for SPECT MPI and CTA that integrates functional and structural information for comprehensive cardiac evaluation. The proposed pipeline performs U-Net-based segmentation on both modalities. On SPECT MPI, only the left ventricle (LV) is extracted, and anatomical landmarks are automatically derived from characteristic LV structures. On CTA, both ventricles are segmented, and their spatial relationship is used to automatically define landmarks at the interventricular septal junction. Scale-space consistency preprocessing and landmark-driven coarse registration are applied to mitigate initial misalignment. Based on this initialization, multiple fine registration methods are evaluated on LV epicardial surface point clouds, including ICP, SICP, CPD, CluReg, FFD, and BCPD-plus-plus. The resulting transformations are then propagated to voxel-level resampling for high-precision SPECT-CTA fusion. In a retrospective cohort of 60 patients, the proposed framework preserved sub-millimeter coronary detail from CTA while accurately overlaying quantitative SPECT perfusion. Among the evaluated methods, BCPD-plus-plus achieved the highest accuracy with a mean point cloud distance of 1.7 mm. By combining robust initialization, comparative fine registration, and voxel-level fusion, the proposed approach provides a practical solution for myocardial ischemia localization and functional evaluation of coronary lesions, while remaining independent of any specific fine registration algorithm.

Multi-hop Question Answering (MHQA) aims to answer questions that require multi-step reasoning. It presents two key challenges: generating correct reasoning paths in response to the complex user queries, and accurately retrieving essential knowledge in the face of potential limitations in large language models (LLMs). Existing approaches primarily rely on prompt-based methods to generate reasoning paths, which are further combined with traditional sparse or dense retrieval to produce the final answer. However, the generation of reasoning paths commonly lacks effective control over the generative process, thus leading the reasoning astray. Meanwhile, the retrieval methods over-rely on knowledge matching or similarity scores rather than evaluating the practical utility of the information, resulting in retrieving homogeneous or non-useful information. Therefore, we propose a Structured Entity-Aware Retrieval with Chain-of-Reasoning Navigator framework named SEARCH-R. Specifically, SEARCH-R trains an end-to-end reasoning path navigator, which is able to provide a powerful sub-question decomposer by fine-tuning the Llama3.1-8B model. Moreover, a novel dependency tree-based retrieval is designed to evaluate the informational contribution of the document quantitatively. Extensive experiments on three challenging multi-hop datasets validate the effectiveness of the proposed framework. The code and dataset are available at: https://github.com/Applied-Machine-Learning-Lab/ACL2026_SEARCH-R.

As LLM agents transition to autonomous digital coworkers, maintaining deterministic goal-directedness in non-linear multi-turn conversations emerged as an architectural bottleneck. We identify and formalize a systemic failure mode termed the Attention Latch in decoder-only autoregressive Transformers. This phenomenon, a behavioral manifestation of Information Over-squashing, occurs when the cumulative probabilistic weight of historical context overrides mid-task updates, causing agents to remain anchored to obsolete constraints despite explicit contradictory instructions. We propose Self-Synthesizing Reasoning Protocols (SSRP), a metacognitive framework that implements a discrete separation between high-level architectural planning (Architect) and turn-by-turn procedural execution (Executive). We evaluate SSRP across 9K trajectories using the MultiWOZ 2.2 dataset and the Aggregate Pivot Accuracy (APA), a novel metric we validate by mapping its scores to the U-shaped 'Lost in the Middle' curve. We present 3 experimental tiers: a shallow recency-based retrieval pilot, a high-entropy SOP, and a semantic hijacked 3-hop Multi-Fact Synthesis task. Our results empirically locate the Attention Stability Boundary, where stateless Vanilla ReAct baselines for GPT 5.4 collapse to 0.1% success while SSRP achieves a 715X Resilience Lift. We demonstrate statistically significant gains across Gemini 3.1 Pro, Claude Sonnet 4.6 and DeepSeek V3.2. Audits confirm SSRP necessity by proving attentional lapse via a recursive reflexion baseline (100% success); decoupling the latch from positional bias through equidistant stress testing (90% accuracy); and formalizing SSRP via the Information Bottleneck principle and granularity ablations. Procedural Integrity audit (98.8% adherence) reveals a Grounding Paradox where high-stability models fail by refusing to hallucinate under retrieval-reasoning contamination.

Biological function emerges from coupled constraints across sequence, structure, regulation, evolution, and cellular context, yet most foundation models in biology are trained within one modality or for a fixed forward task. We present MIMIC, a generative multimodal foundation model trained on our newly curated and aligned dataset, LORE, linking nucleic acid, protein, evolutionary, structural, regulatory, and semantic/contextual modalities within partially observed biomolecular states. MIMIC uses a split-track encoder-decoder architecture to condition on arbitrary subsets of observed modalities and reconstruct or generate missing components of molecular state across the genome, transcriptome, and proteome. Multimodal conditioning consistently improves MIMIC's sequence reconstruction relative to sequence-only inputs, while its learned representations enable state-of-the-art performance on RNA and protein downstream tasks. MIMIC achieves state-of-the-art splicing prediction, and its joint generative formulation enables isoform-aware inference that further improves performance. Beyond prediction, the same generative framework supports constrained design. For RNA, MIMIC identifies corrective edits in a clinically relevant HBB splice-disrupting mutation without reverting it by using evolutionary and structural signals. For proteins, jointly conditioning on shape and surface chemistry of PD-L1 and hACE2 binding sites produces diverse, high-confidence sequences with strong in silico support for target binding. Finally, MIMIC uses experimental context as semantic conditioning to model assay-dependent RNA chemical probing, rather than treating context as a fixed output. Together, these results position MIMIC's aligned multimodal generative modeling as a strong foundation for unifying representation learning, conditional prediction, and constrained biomolecular design within a single model.

Modern self-supervised representation learning methods often relies on empirical heuristics that are not theoretically grounded. In this study we propose HyDeS, a theoretically grounded method based on multi-view mutual information maximization within an hyperspherical space using Shannon differential entropy with a non-parametric von Mises-Fisher density estimator. We show that HyDeS bias the trained model towards focusing on foreground features of the images and perform well on segmentation tasks such as VOC PASCAL, while it lags in fine-grained classification. We provide a detailed analysis of the induced latent space geometry and learning dynamics, that can be used for designing other theoretically grounded self-supervised learning methods.