Large Language Model (LLM) agents are increasingly deployed in multi-agent systems requiring strategic coordination. While recent work has analyzed LLM behavior in two-player games, coalition formation, where $n$ agents dynamically form cooperative groups, remains theoretically uncharacterized. We present the first framework grounding coalition formation in LLM agent networks in hedonic game theory with formal stability guarantees. We introduce the LLM Coalition Formation Game (LCFG), establish sufficient conditions for Nash-stable partitions, and prove complexity results. Our analysis reveals that LLM agents exhibit bounded rationality characterized by $ε$-rational preferences; we provide both deterministic existence guarantees and consistency-driven stability bounds whose predictions are consistent with empirical outcomes. Experiments with GPT-4, Claude-3, and Llama-3 across 2,400 episodes validate our framework: LLM coalitions achieve Nash stability in 73.2% of cases under our Coalition-of-Thought (CoalT) protocol, compared to 58.4% under chain-of-thought and 41.8% under standard prompting ($p < 0.001$). Our framework provides theoretical foundations for designing stable multi-agent LLM systems.

AI tools increasingly guide targeted interventions in healthcare, education, and recruiting. Algorithms score individuals, trigger outreach to those above a threshold (e.g., high-risk or high-value), and encourage them to request service; then providers deliver service to those who request. Standard practice sets the threshold and selects the algorithm to maximize predictive accuracy, assuming that better predictions yield better outcomes. We show that this approach is suboptimal when limited service capacity and probabilistic behavioral responses influence who receives service. In such settings, the optimal score threshold must balance two effects: ensuring all capacity is filled (utilization) and ensuring high-value individuals are served despite competition between requests (cannibalization). We characterize the optimal threshold and prove that policies based solely on predictive accuracy are generally suboptimal. Further, because optimal thresholds vary with service capacity, algorithm selection metrics like AUC, which weight all thresholds equally, are misaligned with operational performance. We introduce a new metric--Operational AUC (OpAUC)--and show it leads to optimal algorithm selection. Finally, we conduct a case study on sepsis early warning data and illustrate the magnitude of improvement that can be achieved from improved threshold and algorithm selection.

Online A/B testing at scale relies on proxy metrics -- short-term, easily-measured signals used in place of slow-moving long-term outcomes. When the proxy-outcome relationship is heterogeneous across user segments, aggregate correlation can mask directional failures akin to Simpson's Paradox, leading to costly ship/no-ship errors. We introduce PROXIMA (Proxy Metric Validation Framework for Online Experiments), a lightweight diagnostic framework that scores proxy reliability through a composite of three complementary dimensions: normalised effect correlation, directional accuracy, and segment-level fragility rate. Unlike surrogate-index approaches that predict long-term treatment effects, PROXIMA directly audits whether a candidate proxy leads to correct launch decisions and flags the user segments where it fails. We validate PROXIMA on two public datasets -- the Criteo Uplift corpus (14M observations, advertising) and KuaiRec (7K users, video recommendation) -- using 80 simulated A/B tests. Early engagement metrics achieve a composite reliability of 0.80 on Criteo and 0.62 on KuaiRec, yielding 98.4% average decision agreement with an oracle policy. Fragility analysis reveals that recommendation domains exhibit substantially higher segment-level heterogeneity (68% fragility) than advertising (13%), yet directional accuracy remains above 96% in both cases. A sensitivity analysis over the weight space confirms that no single component suffices and that the composite provides substantially better discrimination between reliable and unreliable proxies than correlation alone. Code and reproduction scripts are available at: https://github.com/Avinash-Amudala/PROXIMA

Agentic systems built on large language models (LLMs) are increasingly being used for complex security tasks, including binary reverse engineering (RE). Despite recent growth in popularity and capability, these systems continue to face limitations in realistic settings. Cutting-edge systems still fail in complex RE scenarios that involve obfuscation, timing, and unique architecture. In this work, we examine how agentic systems perform reverse engineering tasks with static, dynamic, and hybrid agents. Through an analysis of existing agentic tool usage, we identify several limitations, including token constraints, struggles with obfuscation, and a lack of program guardrails. From these findings, we outline current challenges and position future directions for system designers to overcome from a security perspective.

Targeted amplicon panels are widely used in oncology diagnostics, but providing per-gene performance guarantees for copy number variant (CNV) detection remains challenging due to amplification artifacts, process-mismatch heterogeneity, and limited validation sample sizes. While Bayesian CNV callers naturally quantify per-sample uncertainty, translating this into the frequentist population-level guarantees required for clinical validation, coverage rates, false-positive bounds, and minimum detectable copy-number changes, is a fundamentally different inferential problem. We show empirically that even robust Bayesian credible intervals, including coarsened posteriors and sandwich-adjusted intervals, are severely miscalibrated on panels with small amplicon counts per gene. To address this, we propose a hybrid framework that evaluates Bayesian posterior functionals on validation samples and models the resulting squared losses with a Gamma distribution, yielding tolerance intervals with valid frequentist coverage. Three components make the method practical under real-world constraints: (1) imputation that removes the influence of true CNV-positive samples without requiring known ground truth, (2) regularization to address small sample variability, and (3) evidence-based stratification on the log model evidence to accommodate non-exchangeable noise profiles arising from process mismatch. Evaluated on two targeted amplicon panels using leave-one-out cross-validation, the proposed method achieves single-digit mean absolute coverage error across all genes under both process-matched and unmatched conditions, whereas Bayesian comparators exhibit mean absolute errors exceeding 60\% on clinically relevant genes such as ERBB2.

Accurate detection and segmentation of glomeruli in kidney tissue are essential for diagnostic applications. Traditional deep learning methods primarily rely on semantic segmentation, which often fails to precisely delineate adjacent glomeruli. To address this challenge, we propose a novel glomerulus detection and segmentation model that emphasises boundary separation. Leveraging pathology foundation models, the proposed U-Net-based architecture incorporates a specialised attention decoder designed to highlight critical regions and improve instancelevel segmentation. Experimental evaluations demonstrate that our approach surpasses state-of-the-art methods in both Dice score and Intersection over Union, indicating superior performance in glomerular delineation.

Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing diagnostic models are trained either on a single site or under full multi-site access, making them unsuitable for real-world scenarios where clinical data arrive sequentially from different institutions. This results in limited generalization and severe catastrophic forgetting. This paper presents the first continual learning framework specifically designed for fMRI-based diagnosis across heterogeneous clinical sites. Our framework introduces a structure-aware variational autoencoder that synthesizes realistic FC matrices for both patient and control groups. Built on this generative backbone, we develop a multi-level knowledge distillation strategy that aligns predictions and graph representations between new-site data and replayed samples. To further enhance efficiency, we incorporate a hierarchical contextual bandit scheme for adaptive replay sampling. Experiments on multi-site datasets for major depressive disorder (MDD), schizophrenia (SZ), and autism spectrum disorder (ASD) show that the proposed generative model enhances data augmentation quality, and the overall continual learning framework substantially outperforms existing methods in mitigating catastrophic forgetting. Our code is available at https://github.com/4me808/FORGE.

Modern information access ecosystems consist of mixtures of systems, such as retrieval systems and large language models, and increasingly rely on marketplaces to mediate access to models, tools, and data, making competition between systems inherent to deployment. In such settings, outcomes are shaped not only by benchmark quality but also by competitive pressure, including user switching, routing decisions, and operational constraints. Yet evaluation is still largely conducted on static benchmarks with accuracy-focused measures that assume systems operate in isolation. This mismatch makes it difficult to predict post-deployment success and obscures competitive effects such as early-adoption advantages and market dominance. We introduce Marketplace Evaluation, a simulation-based paradigm that evaluates information access systems as participants in a competitive marketplace. By simulating repeated interactions and evolving user and agent preferences, the framework enables longitudinal evaluation and marketplace-level metrics, such as retention and market share, that complement and can extend beyond traditional accuracy-based metrics. We formalize the framework and outline a research agenda, motivated by business and economics, around marketplace simulation, metrics, optimization, and adoption in evaluation campaigns like TREC.

The classic paradigm of structural biology is that the sequence of a biomolecule (protein, nucleic acid, lipid, etc) determines its conformation (shape) which determines its biological function. Protein folding programs like AlphaFold address this paradigm by predicting the single best conformation given a sequence that defines the molecule. However, biomolecules are not static structures, and their conformational ensemble determines their function. We present the Polyformer -- a generative framework for thermodynamic modeling of polymeric molecules. Given the sequence and temperature (or another thermodynamic variable), the Polyformer generates conformations faithful to the molecule's thermodynamic conformational ensemble. It is the first generative model that solves three problems simultaneously: how does a molecule fold, what is its conformational ensemble, and how does the conformational ensemble change as we change physical temperature. As a concrete test case, we apply Polyformer to protein domains with 50-111 residues and report good agreement of model predictions to Molecular Dynamics (MD) trajectories.

The IEC-61850 GOOSE protocol underpins time-critical communication in modern digital substations but lacks native security mechanisms, leaving it vulnerable to replay, masquerade, and data injection attacks. Intrusion detection in this setting is challenging due to strict latency constraints (sub-4ms) and limited availability of labeled attack data. This paper evaluates whether unsupervised temporal modeling can provide effective and deployable anomaly detection for GOOSE networks. Five models are compared on the ERENO IEC-61850 dataset: a supervised Random Forest baseline, a feedforward Autoencoder, and three recurrent sequence autoencoders (RNN, LSTM, and GRU). The supervised Random Forest achieves the highest detection performance (F1=0.9516) but fails to meet real-time constraints at 21.8ms per prediction. All four unsupervised models satisfy the 4ms requirement, with the GRU achieving the best accuracy to latency tradeoff among them (F1=0.8737 at 1.118ms). A cross-environment evaluation on an independent dataset shows that all models degrade under distribution shift. However, recurrent models retain substantially higher relative performance than the supervised baseline, suggesting that temporal sequence modeling generalizes better than fitting labeled attack distributions. Anomaly thresholds for the unsupervised models are selected on a held out validation partition to avoid test set leakage. These results support unsupervised temporal models as a practical choice for real-time GOOSE intrusion detection, particularly in environments where labeled training data may be unavailable or where large-scale deployment across diverse substations is required.

Synthetic Aperture Radar (SAR) data is inherently complex-valued, while quantum machine learning (QML) models naturally operate in complex Hilbert spaces. This apparent alignment suggests that incorporating both magnitude and phase information into quantum encoding should improve performance in SAR Automatic Target Recognition (ATR). In this work, we systematically evaluate this assumption by comparing five quantum encoding strategies: magnitude-only, joint complex, I/Q-based, preprocessed phase, and pure quantum, under a unified experimental framework on the MSTAR benchmark dataset. Contrary to expectation, we observe a consistent pattern: in hybrid quantum-classical architectures, magnitude-only encoding outperforms all complex-valued strategies, achieving 99.57% accuracy on a 3-class task and 71.19% on an 8-class task, while phase-aware methods provide negligible (~0%) or negative improvements. In contrast, in purely quantum architectures with only 184-224 trainable parameters and no classical components, phase information becomes essential, contributing up to 21.65% improvement in accuracy. These results reveal that the utility of phase information is not inherent to the data, but depends critically on the model architecture. Hybrid models rely on classical components that compensate for missing phase information, whereas purely quantum models require phase to construct discriminative representations. Our findings provide practical design guidelines for encoding complex-valued data in QML and highlight the importance of encoding-architecture co-design in the NISQ era.

Claude Code is an agentic coding tool that can run shell commands, edit files, and call external services on behalf of the user. This study describes its comprehensive architecture by analyzing the publicly available TypeScript source code and further comparing it with OpenClaw, an independent open-source AI agent system that answers many of the same design questions from a different deployment context. Our analysis identifies five human values, philosophies, and needs that motivate the architecture (human decision authority, safety and security, reliable execution, capability amplification, and contextual adaptability) and traces them through thirteen design principles to specific implementation choices. The core of the system is a simple while-loop that calls the model, runs tools, and repeats. Most of the code, however, lives in the systems around this loop: a permission system with seven modes and an ML-based classifier, a five-layer compaction pipeline for context management, four extensibility mechanisms (MCP, plugins, skills, and hooks), a subagent delegation mechanism with worktree isolation, and append-oriented session storage. A comparison with OpenClaw, a multi-channel personal assistant gateway, shows that the same recurring design questions produce different architectural answers when the deployment context changes: from per-action safety classification to perimeter-level access control, from a single CLI loop to an embedded runtime within a gateway control plane, and from context-window extensions to gateway-wide capability registration. We finally identify six open design directions for future agent systems, grounded in recent empirical, architectural, and policy literature.

Retrieval-Augmented Generation (RAG) is a key approach to mitigating the temporal staleness of large language models (LLMs) by grounding responses in up-to-date evidence. Within the RAG pipeline, re-rankers play a pivotal role in selecting the most useful documents from retrieved candidates. However, existing benchmarks predominantly evaluate re-rankers in static settings and do not adequately assess performance under evolving information -- a critical gap, as real-world systems often must choose among temporally different pieces of evidence. To address this limitation, we introduce FRESCO (Factual Recency and Evolving Semantic COnflict), a benchmark for evaluating re-rankers in temporally dynamic contexts. By pairing recency-seeking queries with historical Wikipedia revisions, FRESCO tests whether re-rankers can prioritize factually recent evidence while maintaining semantic relevance. Our evaluation reveals a consistent failure mode across existing re-rankers: a strong bias toward older, semantically rich documents, even when they are factually obsolete. We further investigate an instruction optimization framework to mitigate this issue. By identifying Pareto-optimal instructions that balance Evolving and Non-Evolving Knowledge tasks, we obtain gains of up to 27% on Evolving Knowledge tasks while maintaining competitive performance on Non-Evolving Knowledge tasks.

Traditional conversational travel recommender systems primarily optimize for user relevance and convenience, often reinforcing popular, overcrowded destinations and carbon-intensive travel choices. To address this, we present TRACE (Tourism Recommendation with Agentic Counterfactual Explanations), a multi-agent, LLM-based framework that promotes sustainable tourism through interactive nudging. TRACE uses a modular orchestrator-worker architecture where specialized agents elicit latent sustainability preferences, construct structured user personas, and generate recommendations that balance relevance with environmental impact. A key innovation lies in its use of agentic counterfactual explanations and LLM-driven clarifying questions, which together surface greener alternatives and refine understanding of intent, fostering user reflection without coercion. User studies and semantic alignment analyses demonstrate that TRACE effectively supports sustainable decision-making while preserving recommendation quality and interactive responsiveness. TRACE is implemented on Google's Agent Development Kit, with full code, Docker setup, prompts, and a publicly available demo video to ensure reproducibility. A project summary, including all resources, prompts, and demo access, is available at https://ashmibanerjee.github.io/trace-chatbot.

Retrieval-Augmented Generation (RAG) has become the standard paradigm for grounding Large Language Model outputs in external knowledge. Lumer et al. [1] presented the first systematic evaluation comparing vector-based agentic RAG against hierarchical node-based reasoning systems for financial document QA across 1,200 SEC filings, finding vector-based systems achieved a 68% win rate. Concurrently, the PageIndex framework [2] demonstrated 98.7% accuracy on FinanceBench through purely reasoning-based retrieval. This paper extends their work by: (i) implementing and evaluating three retrieval architectures: Vector RAG, Tree Reasoning, and the proposed Adaptive Hybrid Retrieval (AHR) across financial, legal, and medical domains; (ii) introducing a four-tier query complexity benchmark; and (iii) employing GPT-4-powered LLM-as-judge evaluation. Experiments reveal that Tree Reasoning achieves the highest overall score (0.900), but no single paradigm dominates across all tiers: Vector RAG wins on multi-document synthesis (Tier 4, score 0.900), while the Hybrid AHR achieves the best performance on cross-reference (0.850) and multi-section queries (0.929). Cross-reference recall reaches 100% for tree-based and hybrid approaches versus 91.7% for vector search, quantifying a critical capability gap. Validation on FinanceBench (150 expert-annotated questions on real SEC 10-K and 10-Q filings) confirms and strengthens these findings: Tree Reasoning scores 0.938, Hybrid AHR 0.901, and Vector RAG 0.821, with the Tree--Vector quality gap widening to 11.7 percentage points on real-world documents. These findings support the development of adaptive retrieval systems that dynamically select strategies based on query complexity and document structure. All code and data are publicly available.

This research paper addresses the limitations of semantic search in complex enterprise document ecosystems. Traditional RAG pipelines often fail to capture hierarchical and interconnected information, leading to retrieval inaccuracies. We propose Agentic Knowledge Graphs featuring Recursive Crawling as a robust solution for navigating superseding logic and multi-hop references. Our benchmark evaluation using the Code of Federal Regulations (CFR) demonstrates that this Knowledge Graph-enhanced approach achieves a 70% accuracy improvement over standard vector-based RAG systems, providing exhaustive and precise answers for complex regulatory queries.

Predicting post-surgical seizure outcomes in pharmacoresistant epilepsy is a clinical challenge. Conventional deep-learning approaches operate on static, single-timepoint pre-operative scans, omitting longitudinal morphological changes. We propose \emph{Neuro-Oracle}, a three-stage framework that: (i) distils pre-to-post-operative MRI changes into a compact 512-dimensional trajectory vector using a 3D Siamese contrastive encoder; (ii) retrieves historically similar surgical trajectories from a population archive via nearest-neighbour search; and (iii) synthesises a natural-language prognosis grounded in the retrieved evidence using a quantized Llama-3-8B reasoning agent. Evaluations are conducted on the public EPISURG dataset ($N{=}268$ longitudinally paired cases) using five-fold stratified cross-validation. Since ground-truth seizure-freedom scores are unavailable, we utilize a clinical proxy label based on the resection type. We acknowledge that the network representations may potentially learn the anatomical features of the resection cavities (i.e., temporal versus non-temporal locations) rather than true prognostic morphometry. Our current evaluation thus serves mainly as a proof-of-concept for the trajectory-aware retrieval architecture. Trajectory-based classifiers achieve AUC values between 0.834 and 0.905, compared with 0.793 for a single-timepoint ResNet-50 baseline. The Neuro-Oracle agent (M5) matches the AUC of purely discriminative trajectory classifiers (0.867) while producing structured justifications with zero observed hallucinations under our audit protocol. A Siamese Diversity Ensemble (M6) of trajectory-space classifiers attains an AUC of 0.905 without language-model overhead.

This thesis is an exposition of Ollivier-Ricci Curvature of metric spaces as introduced by Yann Ollivier, which is based upon the 1-Wasserstein Distance and optimal transport theory. We present some of the major results and proofs that connect Ollivier-Ricci curvature with classical Ricci curvature of Riemannian manifolds, including extensions of various theoretical bounds and theorems such as Bonnet-Myers and Levy-Gromov. Then we shift to results introduced by Lin-Lu-Yau on an extension of Ollivier-Ricci curvature on graphs, as well as the work of Jost-Liu on proving various combinatorial bounds for graph Ollivier-Ricci curvature. At the end of this thesis we present novel ideas and proofs regarding extensions of these results to directed graphs, and finally applications of graph-based Ollivier-Ricci curvature to various algorithms in network science and graph machine learning.

This work develops machine learning approaches to classify structured light wave beams developing random speckle disturbances as they propagate through turbulent atmospheres. Beam propagation is modeled by the numerical simulation of a stochastic paraxial equation. We design convolutional neural networks tailored for this specific application and use them for a classification model with one-hot encoding. To address the challenge of potentially limited available data, we develop a prediction-based generative diffusion model to provide additional data during classifier training. We show that a Bregman distance minimization during the learning step improves the quality of the generation of high-frequency modes.

Electroencephalography (EEG) has become one of the key modalities underpinning brain-computer interfaces (BCIs) due to its high temporal resolution, rapid responsiveness, non-invasiveness, low cost, and portability. However, EEG signals are substantially inferior to intracranial EEG (iEEG) in signal-to-noise ratio and local spatial resolution, whereas iEEG suffers from extremely limited clinical accessibility owing to its invasive nature, hindering widespread application. To address this challenge, this study proposes a unified data-and prior knowledge-driven framework for EEG-iEEG representational enhancement. Guided by the principle that "geometric structure dictates function", the framework maps static cortical anatomy onto dynamic constraints governing neural signal propagation and integrates general-purpose neural representations extracted by a pre-trained large EEG model to explicitly model signal transmission through the brain. Enhanced EEG signals are then synthesized via a multidimensional representation diffusion process. Numerous experimental results demonstrate that the generated enhanced EEG signals effectively recover the neural activity patterns lost during propagation through the brain. This finding indicates that the performance ceiling of BCIs is constrained not only by acquisition hardware but also by the depth to which the generative model resolves the mechanisms of neural signal propagation. Collectively, the proposed framework provides a viable pathway toward acquiring high-fidelity neural signals at low cost.

Deep Neural Networks (DNNs) are vulnerable to elaborately designed adversarial noise, although they have achieved extraordinary success in many tasks. Compared with DNNs, the human visual system is highly robust. However, it is unclear how the human visual system defends against adversarial attacks, especially the role of the early visual system and its influence on the brain manifold. Due to retina gap junctions being crucial for the denoising function in the early visual system, we combine a retina gap junction-based filter, G-filter, with DNN as an abstract human visual system model called the biological hybrid model. We adopt this model to study the defense performance of retina gap junctions and their impact on the brain manifold. Compared with other defense methods, the biological hybrid model is more robust and can be further improved by introducing noise during training. Next, we analyze the manifold and its decision boundary of the biological hybrid model from a geometry perspective. The results show that the biological hybrid model has a unique 2D decision boundary with high nonlinearity and a lower curvature of the decision boundary of the manifold compared to other defense methods. The transforming manifold may account for the high robustness of the biological hybrid model. Finally, to dissect G-filter and clarify its internal mechanism, we borrow the Neural Ordinary Differential Equation (ODE) concept and rewrite G-filter into an equivalent recurrent neural network. The results show that the decision boundary of the model's manifold will gradually change with time and eventually reach a steady state, which is modulated by gap junction conductance, revealing the influence of retina gap junctions on the brain manifold is a gradually evolving process.

Predicting real-world events from live market signals demands systems that fuse qualitative news with quantitative order-book dynamics under strict temporal discipline -- a challenge existing benchmarks fail to capture. We present \textbf{PolyBench}, a multimodal benchmark derived from Polymarket that records point-in-time cross-sections of 38,666 binary prediction markets spanning 4,997 events, synchronously coupling each snapshot with a Central Limit Order Book (CLOB) state and a real-time news stream. Using PolyBench, we evaluate seven state-of-the-art Large Language Models -- spanning open- and closed-source families -- generating 36,165 predictions under identical, timestamp-locked market states collected between February 6 and 12, 2026. Our multidimensional framework assesses directional accuracy, our proposed Confidence-Weighted Return (CWR), Annualized Percentage Yield (APY), and Sharpe ratio via realistic order-book execution simulation. The results reveal a pronounced performance divergence: only two of seven models achieve positive financial returns -- MiMo-V2-Flash at \textbf{17.6%} CWR and Gemini-3-Flash at 6.2% CWR -- while the remaining five incur losses despite uniformly high stated confidence. These findings highlight the gap between surface-level language fluency and genuine probabilistic reasoning under live market uncertainty, and establish PolyBench as a contamination-proof, financially-grounded evaluation standard for future LLM research. Our dataset and code available at \underline{\href{https://github.com/PolyBench/PolyBench}{https://github.com/PolyBench/PolyBench}}.

Large language models have demonstrated impressive performance across many domains of mathematics and physics. One natural question is whether such models can support research in highly abstract theoretical fields such as quantum field theory and string theory. Evaluating this possibility faces an immediate challenge: correctness in these domains is layered, tacit, and fundamentally non-binary. Standard answer-matching metrics fail to capture whether intermediate conceptual steps are properly reconstructed or whether implicit structural constraints are respected. We construct a compact expert-curated dataset of twelve questions spanning core areas of quantum field theory and string theory, and introduce a five-level grading rubric separating statement correctness, key concept awareness, reasoning chain presence, tacit step reconstruction, and enrichment. Evaluating multiple contemporary LLMs, we observe near-ceiling performance on explicit derivations within stable conceptual frames, but systematic degradation when tasks require reconstruction of omitted reasoning steps or reorganization of representations under global consistency constraints. These failures are driven not only by missing intermediate steps, but by an instability in representation selection: models often fail to identify the correct conceptual framing required to resolve implicit tensions. We argue that highly abstract theoretical physics provides a uniquely sensitive lens on the epistemic limits of current evaluation paradigms.

Large self-supervised speech (SSL) models achieve strong downstream performance, but their size limits deployment in resource-constrained settings. We present HArnESS, an Arabic-centric self-supervised speech model family trained from scratch with iterative self-distillation, together with lightweight student variants that offer strong accuracy-efficiency trade-offs on Automatic Speech Recognition (ASR), Dialect Identification (DID), and Speech Emotion Recognition (SER). Our approach begins with a large bilingual Arabic-English teacher and progressively distills its knowledge into compressed student models while preserving Arabic-relevant acoustic and paralinguistic representations. We further study PCA-based compression of the teacher supervision signal to better match the capacity of shallow and thin students. Compared with HuBERT and XLS-R, HArnESS consistently improves performance on Arabic downstream tasks, while the compressed models remain competitive under substantial structural reduction. These results position HArnESS as a practical and accessible Arabic-centric SSL foundation for real-world speech applications.

Buildings and data centers (DCs) are energy-intensive sectors, playing a critical role to achieve the low-carbon and sustainable energy transition targets. To this end, integrated energy system (IES) that incorporates diverse renewables, energy generation, conversion, and storage technologies to enable coordinated multi-energy supply have been widely investigated for both buildings and DCs. However, few works consider the two sectors jointly within IES to exploit their substantial synergistic benefits. Meanwhile, the operational optimization of IES remains challenging due to the difficulty to predict the multi-energy demand and supply accurately. To address these gaps, this paper investigates IES for coordinated multi-energy supply of buildings and DC, where the waste heat from DCs is recovered and reused to enhance energy efficiency. Moreover, an end-to-end learning-based method is proposed for the operational optimization of IES under uncertainty. Unlike conventional predict-then-optimize approaches, the proposed method integrates the training of prediction models for uncertain variables with the constrained optimization of IES into a unified learning framework, guiding the training of prediction models to improve operational performance, rather than prediction accuracy, thereby mitigating the impacts of predictions errors. Case studies based on real-world datasets show that the proposed methods improves the operational performance of IES by about 7-9% compared to existing predict-then-optimize methods. In addition, coordinating buildings and DCs within IES shows substantial economic benefits. In particular, the waste heat recovery from DCs leads to approximately 10% of total energy cost reduction of the IES.

The rapid aging of global populations has created an urgent need for intelligent healthcare monitoring systems to ensure the safety of elderly individuals living independently. Existing cloud-centric platforms face critical limitations, including high latency unsuitable for emergency response, privacy risks from continuous transmission of sensitive data, and limited, single-channel alert mechanisms lacking scalability and context awareness. This paper proposes an edge-cloud collaborative architecture that addresses these challenges through real-time multi-modal sensor fusion, a four-dimensional risk assessment model, and a three-level emergency response system. The framework adopts a five-layer design - device, edge, service, data, and application layers - enabling real-time risk evaluation with end-to-end alert latency under three seconds. At the edge, a weighted multi-modal fusion algorithm integrates data from five sensor types with confidence propagation. A unified risk score is generated by combining fall probability, physiological indicators, behavioral patterns, and sensor anomaly metrics. Based on dynamic thresholds, a three-tier notification system coordinates responses among family members, community doctors, and nearby volunteers. Experiments on CASAS, MIMIC-III, and SisFall datasets show that the approach achieves 91% activity recognition accuracy and an 84% anomaly detection F1-score, outperforming single-sensor methods. Deployment on Raspberry Pi 4 gateways demonstrates sub-100 ms inference latency while preserving privacy by keeping raw data local. This architecture advances practical, privacy-preserving, and responsive elderly care systems.

Reproducibility must validate architectural robustness, not just numerical accuracy. We evaluate ColBERT-v2 and ConstBERT across five dimensions, finding that while ConstBERT reproduces within 0.05% MRR@10 on MS-MARCO, both models show a drop of 86-97% on long, narrative queries (TREC ToT 2025). Ablations prove this failure is architectural: performance plateaus at 20 words because the MaxSim operator's uniform token weighting cannot distinguish signal from filler noise. Furthermore, undocumented backend parameters create an 8-point gap due to ConstBERT's sparse centroid coverage, and fine-tuning with 3x more data actually degrades performance by up to 29%. We conclude that architectural constraints in multi-vector retrieval cannot be overcome by adaptation alone. Code: https://github.com/utshabkg/multi-vector-reproducibility.

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; yet substantial proportion of patients exhibit intrinsic or acquired resistance, making accurate pre-treatment response prediction a critical unmet need. Transcriptomics-based biomarkers derived from bulk and single-cell RNA sequencing (scRNA-seq) offer a promising avenue for capturing tumour-immune interactions, yet the cross-cohort generalisability of existing prediction models remains unclear.We systematically benchmark nine state-of-the-art transcriptomic ICI response predictors, five bulk RNA-seq-based models (COMPASS, IRNet, NetBio, IKCScore, and TNBC-ICI) and four scRNA-seq-based models (PRECISE, DeepGeneX, Tres and scCURE), using publicly available independent datasets unseen during model development. Overall, predictive performance was modest: bulk RNA-seq models performed at or near chance level across most cohorts, while scRNA-seq models showed only marginal improvements. Pathway-level analyses revealed sparse and inconsistent biomarker signals across models. Although scRNA-seq-based predictors converged on immune-related programs such as allograft rejection, bulk RNA-seq-based models exhibited little reproducible overlap. PRECISE and NetBio identified the most coherent immune-related themes, whereas IRNet predominantly captured metabolic pathways weakly aligned with ICI biology. Together, these findings demonstrate the limited cross-cohort robustness and biological consistency of current transcriptomic ICI prediction models, underscoring the need for improved domain adaptation, standardised preprocessing, and biologically grounded model design.

A deep neural network (DNN) has been developed to accurately predict nuclear charge density distributions for nuclei with proton numbers $Z \geq 8$. By incorporating essential nuclear structure features, the model achieves a significant improvement in predictive accuracy over conventional methods. The charge density distributions are analyzed using a Fourier-Bessel (FB) series expansion, and the DNN is trained on a comprehensive dataset derived from relativistic continuum Hartree-Bogoliubov (RCHB) theory calculations. The model demonstrates exceptional performance, with root-mean-square deviations of 0.0123 fm and 0.0198 fm for charge radii on the training and validation sets, respectively, remarkably surpassing the precision of the original RCHB calculations. Beyond advancing nuclear physics research, this high-precision model provides critical data for applications in atomic physics, nuclear astrophysics, and related fields.

This paper presents a smartphone-based imaging system capable of quantifying the concentration of an assortment of biological/chemical assay samples. The main objective is to construct an image database which characterizes the relationship between color information and concentrations of the biological/chemical assay sample. For this aim, a designated optical setup combined with image processing and data analyzing techniques was implemented. A series of experiments conducted on selected assays, including fluorescein, RNA Mango, homogenized milk and yeast have demonstrated that the proposed system estimates the concentration of fluorescent materials and colloidal mixtures comparable to currently used commercial and laboratory instruments. Furthermore, by utilizing the camera and computational power of smartphones, eventual development can be directed toward extremely compact, inexpensive and portable analysis and diagnostic systems which will allow experiments and tests to be conducted in remote or impoverished areas.